Postdoc in cell and molecular biology

Description of the position

Title of the project: Role of primary cilia in the activation of Gli transcription factors in Hedgehog signaling

Project description

Cancer is a disease of transcription factors - they drive tumor growth, metastasis, and prevent cell death in cancerous tissue. Gli proteins are transcription factors involved in many tumors. The mechanisms of the transition of Gli proteins into active drivers of transcription is poorly understood. To discover the molecular foundations of the regulation of Gli proteins in development and disease, you will use state-of-the-art techniques ranging from bioinformatics, through genetic manipulations to quantitative proteomics and confocal microscopy both in cell culture and in vivo. For more information, please visit our website: http://lmcs.cent.uw.edu.pl/

Requirements:

You need to be:

• Creative and an analytical thinker
• Willing to take initiative in big-picture thinking, experimental design, and troubleshooting
• Passionate about hard work in a high-pressure environment

Other requirements:

• Solid publication record in peer-reviewed journals
• Ability to communicate fluently in English
• PhD degree in biology, medicine, pharmacy, or related fields

Preferred, but not strictly required:

• Experience in molecular cloning, cell culture, proteomics, animal models and/or fluorescence imaging

We offer:

• An environment that pushes you to excel, fostering your creativity, autonomy, and personal growth
• Strong mentoring that will help you develop into a mature and well-rounded scientist
• Access to state-of-the-art equipment
• Opportunities for interdisciplinary and international collaborations
• Competitive salary

Other

Keywords: Hedgehog signaling, cell signaling, oncogene, cell transport, primary cilia

Salary: Negotiable

Maximum period of contract/stipend: Negotiable