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Post-doc position in the Institute of Biochemistry and Biophysics

Employer
Global Academy Jobs
Location
Poland
Closing date
Oct 13, 2019

Job Details

A postdoc position is available in the Institute of Biochemistry and Biophysics of Polish Academy of Sciences in Warsaw. The laboratory is located in one of the best research institutions in Poland. The home institute is very well-equipped and localized in the Ochota research campus, where other life sciences institutes are placed.

Project title: Mitochondrial double-stranded RNA: its origin, turnover and involvement in human diseases.
The project is carried out within the FIRST TEAM programme of the Foundation for Polish Science
We are looking for a highly motivated candidate who would like to join a mitochondrial research group lead by Dr. Roman Szczesny. The main aim of the project is to gain insight into double-stranded RNA metabolism in human mitochondria.

In collaboration with a few other teams we have recently found that the transcription of the mitochondrial genome is a major source of dsRNA in human (Dhir, Borowski.... Szczesny & Proudfoot, Nature, 2018). We discovered that dsRNA can be released from mitochondria, which results in activation of the innate immune system and can contribute to human disease. We revealed that the mitochondrial degradosome, a complex of RNA helicase SUV3 and ribonuclease PNPase, is responsible for controlling the levels of mitochondrial dsRNA (mt-dsRNA). To identify other proteins involved in mt-dsRNA metabolism we conducted a genome-wide siRNA screen, where the level of mt-dsRNA was measured by high-throughput fluorescent microscopy. This resulted in the identification of several putative factors related to mt-dsRNA, including known mtRNA players as well as proteins whose link to mtRNA metabolism was unexpected.
The project mostly builds on our yet unpublished results and will be the continuation of our research into dsRNA of mitochondrial origin. Our long term goal is to understand the molecular mechanisms of dsRNA metabolism in human mitochondria and explore potential links between mt-dsRNA and human diseases.

Key responsibilities include:
Performing functional studies of selected mt-dsRNA factors.
Protein purification and biochemical assays.

We offer:
Ambitious scientific goals, friendly and stimulating scientific environment, well-equipped laboratory, ability to apply various research strategies (including high-throughput siRNA screenings, proteomics, NGS-based studies
Remuneration:
~6000 PLN/month (net)

Selection process:
Application deadline is 14-10-2019, 12:00:00 (local time).
Selected candidates will be invited for interview (interview via Skype is possible).

Required documents:
CV including scientific achievements, short description of research project(s) conducted so far, list of known/used methods by the applicant, any other relevant information (prizes, honors, IT skills, organization of scientific meetings, experience in supervision of students/teaching)
Copy of PhD diploma or any other document which confirms PhD promotion.
List of publications, if applicable.
Contact information for at least one professional reference.
Optional documents: reference letter(s), motivation letter - summary and relevance of your current research and why you are interested in the position (maximum 1 page, Calibri, 12 pts)
All documents (written in English or Polish) should be merged into one pdf file. The file should be named as follows: Last name_First name_CV.pdf
After evaluation of submitted documents selected candidates will be invited for an interview.

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