Research Associate - Formulations - Durham

Precision BioSciences
Durham, North Carolina
Oct 10, 2019
Oct 12, 2019
Organization Type
Assist in design and execution of experiments to provide support for mRNA process development and lipid nanoparticle formulations for research applications using ARCUS nucleases.

Essential Duties and Responsibilities

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position. This list contains the major duties and requirements of the job and is not all-inclusive. Incumbent(s) may be expected to perform role-related duties other than those contained in this document.
  • Formulate in-house lipid nanoparticle formulations containing nucleic acids
  • Assess formulations and mRNA for quality, potency and toxicity
  • Generate and compile analytical data used to issue certificate of analysis (CoA) for each batch of lipid nanoparticles before use in research applications
  • Provide formulations with ARCUS nucleases to research teams for non-clinical studies
  • Maintain cell lines for use in research studies and assist in general operation of the cell culture and molecular lab
  • Maintain accurate records in Electronic Lab Notebook (ELN) system and assist in the organization and tracking of formulations; write reports and communicate results to the Formulation team
  • Maintain lab equipment, including calibrations, log books and general cleaning of glassware; order lab supplies and maintain consumables as needed
  • Prepare sterile filtered buffers, reagents and formulations as well as assess sterility of prepared solutions (endotoxin assay)

The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.


  • BS in chemistry, biology, or engineering, or equivalent, with a minimum of 4 years related lab experience and/or training or Masters degree with 2 years related lab experience
  • Extensive experience with aseptic techniques
  • Extensive experience in maintaining adherent and suspension cell lines
  • Extensive experience performing 96 well based assays

  • Experience with culturing of primary cell lines
  • Experience with lipids and lipid based nanoparticles for nucleic acid delivery
  • Experience with PCR, ddPCR, gel electrophoresis, and indel analysis as well as nucleic acid (mRNA and pDNA) production (amplification, purification, characterization)

Travel Requirements
  • This position may require occasional travel

Precision BioSciences is dedicated to improving life through its proprietary genome editing platform, ARCUS. Precision BioSciences leverages ARCUS in the development of its product candidates which are designed to treat human diseases and create healthy and sustainable food and agriculture solutions. Precision BioSciences is actively developing product candidates in three innovative areas: allogeneic CAR T immunotherapy, in vivo gene correction, and food.

Precision BioSciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, disability, genetic information, marital status, amnesty, or status as a covered veteran in accordance with applicable federal, state and local laws. Precision BioSciences complies with applicable state and local laws governing non-discrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including, but not limited to, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.

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