Scientist - Pharmacokinetics & Drug Metabolism

South San Francisco, California
Oct 09, 2019
Oct 13, 2019
Organization Type
The department of pharmacokinetics and drug metabolism (PKDM) within Amgen is dedicated to the discovery and development of novel effective, safe medicines. The Scientist will work in a team environment to characterize the absorption, distribution, metabolism, excretion and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to design promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings.

The responsibilities of a PKDM Scientist are to develop and routinely employ in vitro and bioanalytical methods for the quantitative and qualitative analysis of new small molecule drug candidates and metabolites in plasma, tissues, and other biological matrices. The role will require data interpretation and communication of results to project team representatives in support of drug discovery and development.

The Scientist will work as a member of the small molecule ADME group and will be responsible for executing enzyme kinetics, in vitro inhibition, metabolite identification, and bioanalytical experiments. Should be able to assist in troubleshooting when instrument or assay problems arise. Other responsibilities will include basic biochemistry research, electronic laboratory notebook keeping and communication of results to project teams.

Basic Qualifications

Doctorate degree


Master's Degree and 4 years of scientific experience


Bachelor's Degree and 6 years of scientific experience

Preferred Qualifications

PhD or MS in chemistry, biochemistry

Experience with operation, troubleshooting, and data interpretation of a mass spectrometer

Experience with operation of automated liquid sample handling instruments and experience with analysis of radiolabeled compounds

Proven ability to execute experiments to quantitate molecular entities by mass spectrometry in support of both drug discovery and early development programs

An excellent understanding of preclinical ADME in vitro and bioanalytical techniques and an individual that can work collaboratively in a fast-paced work environment

Excellent oral and written communication skills and be able to excel in a highly collaborative, matrixed team environment.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

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