Principal Scientist, In Vitro Sciences / Assay Development - South San Francisco

Maze Therapeutics
South San Francisco, California
Nov 08, 2019
Nov 15, 2019
Organization Type
We Are Genetic Navigators bringing together passionate, creative and dedicated professionals to join a rapidly-growing startup on our mission to translate novel genetic insights into lifesaving medicines. We are integrating human genetics and functional genomics to decode the mysteries of genetic modifiers, leading us to new medicines we'll develop for a range of severe diseases.

We are seeking highly qualified in vitro scientist and leader with extensive experience in
biochemical and cellular assays for target validation and in vitro pharmacology. The successful candidate will have expertise in biochemistry and/or enzymology and will be a primary lead as it relates to biochemical assay development and small molecule screening. Additional experience with cellular assays is important. Applicants must feel comfortable with the fast pace of a small biotech company and have the flexibility to work on multiple projects.

Your Role in Navigating The Maze:
  • Conduct and supervise in vitro studies to determine on-target and off-target activity in
    biochemical and/or cellular assays across multiple projects.
  • Lead assay development group and manage the application of automation and informatics activities to provide regular high quality assay results that help drive project team decision.
  • In vivo experience is a plus, as you will collaborate with in vivo for new studies.
  • Serve as the SME for biochemical assay development and enzymology; lead an in vitro sciences / assay development group over time.
  • Manage, process, analyze and present data.
  • Assist with the coordination of studies with CROs as necessary.

Your Navigation Tools:
  • PhD in relevant field with 8+ years' experience with in vitro biochemical and cell-based assay development and screening to drive small molecule optimization programs.
  • Comprehensive working knowledge of biochemistry and small molecule screening.
  • Familiarity with new technologies, and an openness to their utilization.
  • Experience with mammalian cell culture.
  • Solid knowledge of automation applications for small molecule screening, data analysis, and pharmacology concepts.
  • Experience with biophysical assays a plus.
  • Experience representing in vitro assay development and screening in cross-functional project teams.
  • Detail oriented and highly organized.
  • Management/supervisory experience is required.
  • Level will be commensurate with experience.

If you're ready to Enter The Maze, send your resume to .

Maze Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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