Scientist / Senior Associate Scientist, Formulations Development

Recruiter
SystImmune, Inc.
Location
Redmond, Washington
Posted
Nov 03, 2019
Closes
Nov 21, 2019
Ref
7b6aca3f2ebc
Sector
Science
Organization Type
Corporate
Located in Redmond WA, SystImmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic bi-specific, and tri-specific antibodies, as well as antibody-drug conjugates (ADC's). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor. We are a group of highly experienced immuno-oncology scientists utilizing several technology platforms to develop world class advanced antibody-based drug therapies.

Essential Duties and Responsibilities
  • Lead pre-clinical and clinical formulation development and stability study for antibody / antibody drug conjugate;
  • Support research team in candidate optimization, selection and validation;
  • Perform UF/DF, HPLC/UPLC, CE, MFI, Osmolality, viscosity, solubility, DLS, and other biophysical techniques;
  • Experience in process transfer and documentation to support manufacturing in China. Strong communication and writing skills in both Mandarin and English are highly preferred;
  • Write and review Standard Operating Procedures (SOP);
  • Participate in timeline planning and decision-making regarding research and PD priorities of company or department and provide information on feasibility of prospective projects;
  • Other duties as assigned.

Education and Experience
  • PhD + 2 years experience or MS with 5+ years experience in protein sciences or a related department. Industry and/or antibody experience a plus;
  • Experience in high throughput screening and solution protein formulation development;
  • Hands-on experience and trouble-shooting proficiency with HPLC/UPLC;
  • Knowledge of biophysical techniques for protein characterization and stability is a must;
  • Ability to design and execute experiments independently;

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