Sr. Scientist, Analytical Development

Expiring today

Recruiter
Molecular Templates, Inc.
Location
Austin, Texas
Posted
Nov 08, 2019
Closes
Nov 17, 2019
Ref
821e4babccf3
Organization Type
Corporate
Company Description:

Molecular Templates is a clinical stage biopharmaceutical company focused on the discovery and development of differentiated, targeted, biologic therapeutics for cancer. We believe our proprietary biologic drug platform technology, referred to as engineered toxin bodies, or ETBs, provides a differentiated mechanism of action that may address some of the limitations associated with currently available cancer therapeutics. ETBs utilize a genetically engineered form of Shiga-like Toxin A subunit, or SLTA, a ribosome inactivating bacterial protein, that can be targeted to specifically destroy cancer cells. Additional information about Molecular Templates can be obtained at www.mtem.com.

Position Overview:

The position of Senior Scientist, Analytical Development will lead the development and optimization of analytical methods using biophysical/biochemical technology that will be used for protein-based Drug Substance and Drug Product lot release and characterization. The successful candidate will bring in and establish existing and emerging technology to be utilized to support i) development, optimization and characterization of the manufacturing process, ii) formulation, stability and forced degradation studies of the drug substance and drug product. He/she will be responsible for internal/external tech transfer and will collaborate with diverse partners including but not limited to R&D, PD, QC, QA, Manufacturing and Facilities as well as external CROs.

The successful Senior Scientist, Analytical Development is a strong scientific leader that designs key experiments, interprets data and effectively communicates information or risk mitigation strategies that drive critical decisions amongst the technical, quality and pre-clinical groups.

Job Responsibilities will include:
  • Responsible for analytical method development, optimization and testing of phase appropriate analytical methods for protein therapeutics using biophysical/biochemical technology platforms; tech-transfer to internal or external laboratories
  • Responsible for analytical testing of formulation development, stability and forced degradation studies and characterization of drug product and drug substance, as well as in-process intermediates
  • Guides and provides technical expertise to Research Associates and/or Scientists in an assay development and/or a routine test setting in order to deliver key data that support PD and QC efforts
  • Provides expertise in a broad spectrum of HPLC analytical based techniques: SEC, IEC, HIC, RP-HPLC to support protein characterization
  • Provides in-depth understanding and troubleshooting capability of additional advanced analytical instrumentation and techniques (including but not limited to CE-SDS, CZE, iCIEF, MALS, DLS, DSF, AF4, LC-MS/MS, AUC, ELISA, SDS-PAGE, UV-Vis spectrophotometry and BCA/Bradford) to facilitate process understanding and modifications that may impact product and process related impurities
  • May serve as a scientific liaison for outsourced assay development, technology transfer and data management in a CDMO environment
  • Expected to be informed on matters of state-of-the-art or innovative technologies that advance protein characterization and analytical methods

Qualifications:
  • PhD in a relevant area of specialization (analytical chemistry, protein chemistry, biochemical engineering, biological sciences, or biochemistry), plus 3+ years of experience in life sciences including 1+ years in an analytical development role. Ideally, 3+ years bio/pharma experience in a similar role is preferred. Exceptional MSc candidates with 5+ years, or BSc candidates with 8+ years, working experience in the life sciences will also be considered.
  • Demonstrated thorough knowledge of the biophysical/biochemical analytical methods relevant for protein therapeutics
  • Extensive experience in analytical method development for proteins using biophysical/biochemical technology platforms
  • Understanding of ICH/FDA guidelines for method qualification is a plus but not required
  • Skill in writing developmental and technical reports and contributing to regulatory submission
  • Strong verbal and written communication skills and effective interpersonal, technical discretion and troubleshooting skills are essential
  • Must be a team player, strong critical thinker, exhibit a willingness to meet project timelines and multitask effectively in a dynamic fast-paced environment under challenging timelines
  • Demonstrated history of working independently, with minimal supervision, and managing multiple projects
  • Strong attention to detail supported by excellent time management and organizational skills
  • Proficient or familiar with Microsoft based Windows programs: Word, Excel and Powerpoint as well as analytical software such as Empower or Softmax Pro and statistical software such as GraphPad, Minitab, JMP or Spotfire

Reporting Structure:

This position currently has no supervisory responsibilities. This position reports to Manager, Analytical Development (Process Sciences Team).

Molecular Templates, Inc. is an Equal Opportunity Employer and offers competitive salaries and benefits.

Molecular Templates Inc https://mtem.isolvedhire.com

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