Scientist I - Cell Biologist

Frederick National Laboratory for Cancer Research
Frederick, Maryland
Oct 31, 2019
Nov 20, 2019
Organization Type
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

  • Provide cell biology support to the FNL/NCI RAS Initiative and work closely with a highly collaborative multidisciplinary team of chemists, biochemists, biophysicists, and structural/cell/molecular biologists to develop and optimize pharmaceutical agents for use as RAS inhibitors
  • Develop and execute on strategies to evaluate drug activity and mechanism
  • Design and execute experiments; accurately record, analyze, and present data to the team/senior leadership
  • Develop assays and identify technologies to address key questions and drive the drug discovery process

  • Possession of a PhD from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in molecular or cell biology, pharmacology, molecular toxicology or similar discipline. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • No work experience is required beyond the education requirements
  • Strong expertise in cancer cell biology, drug discovery approaches, and cell-based assays
  • Strength in designing and performing experiments to measure target engagement, pathway modulation, and therapeutic sensitivity in response to compounds
  • Experience in Western blotting, real-time PCR, immunoprecipitation, siRNA/shRNA, PPI assays (co-immunoprecipitation, nanoBRET)
  • Must be able to obtain and maintain a security clearance

  • 2 years of post-doctoral research
  • Expertise in the design and execution of molecular biological and biochemical or cellular experiments to determine the effects of therapeutics on biological systems
  • Understanding of the drug discovery process from relevant pharmaceutical experience
  • Experience in protein:protein interaction (e.g. HTRF or BRET) assay design and development
  • Experience working with RAS proteins, understanding RAS biology
  • Able to balance workload over multiple projects
  • Excellent communication and interpersonal skills
  • Ability to work independently and collaborate in a fast-paced team environment

  • Candidate will be working with or have the potential for exposure to infectious material(s) or Other Potentially Infectious Materials (OPIM), requiring medical clearance and immunization in accordance with protocol requirements
Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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