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Research Fellow in Cancer and Genomic Sciences

Employer
Global Academy Jobs
Location
United Kingdom
Salary
£30,942 - £42,792
Closing date
Dec 10, 2019

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Job Details

Job Summary:

Applications are invited for two highly motivated and organised post-doctoral research fellows to join the Stewart laboratory, based at the University of Birmingham, to work on understanding how inherited deficiencies in components of the DNA damage response, particularly proteins involved in DNA repair and/or DNA replication, contribute to the development of human disease (for examples see: Ogi et al (2012) PLoS Genet 8:e1002945; Murray et al (2015) Am J Hum Genet 96:412-24; Harley et al (2016) Nat Genet 48:36-43; Byrd et al (2016) PLoS Genet 12:e1005945).

Ongoing research projects within the laboratory focus on characterising the impact of patient-associated mutations in known DNA repair/replication genes on genome stability, the identification of novel human disease genes associated with defective DNA repair/replication and identifying roles for previously uncharacterised genes/proteins in the DNA damage response (for example: Higgs et al (2015) Mol Cell 59:462-77).

Candidates will be expected to undertake novel, cutting-edge, laboratory-based research within the field of the DNA damage response and replication, specified within a CR-UK funded research programme.

Main Duties/Responsibilities:
  • To plan and develop research activity as outlined in the grant proposal as well as novel research directions, with assistance of a mentor if required.
  • To contribute to writing grant applications for research funding
  • Critically review grant applications and research publications
  • Analyse and interpret the results of own research and generate original ideas based on outcomes
  • Design a successful programme of investigation, managing individual components of the study from the start of the project to dissemination of findings within set timeframes
  • Evaluate methods and techniques used and results obtained by other researchers and relate such evaluations appropriately to your own work
  • Present research results through publication or other recognised forms of output, e.g. peer-reviewed journals, reports and conference presentations at a national/international level
  • Contribute to the work of the research team as a whole; through dialogue with colleagues, generation of ideas, contributing to preparation of grant applications, advising on study design, problem solving etc.
  • Make and contribute to decisions on day-to-day matters that affect their own work and that of the team
  • Keep abreast of the literature and maintain a good working knowledge of the background and current developments in the field of the project
  • Attend research seminars, meetings and conferences, and undertake training courses where required
  • Build internal contacts and participate in internal networks for the exchange of information and for future collaboration
  • Be aware of risks in the work environment and contribute to COSSH assessments when appropriate
  • To supervise students on research related work and provide guidance to PhD students where appropriate to the discipline
  • To contribute to developing new models, techniques and methods
  • To undertake management/administration arising from research
  • To provide guidance, as required, to support staff and any students who may be assisting with the research
  • To deal with problems that may affect the achievement of research objectives and deadlines
  • Promotes equality and values diversity acting as a role model and fostering an inclusive working culture.


Person Specification:
  • Ph.D. (or near to completion) and previous experience within the field of DNA damage signalling, DNA repair and/or DNA replication
  • At least 1 first author publication in a peer-reviewed scientific journal
  • Practical experience with in vitro mammalian cell (including making retrovirus and lentiviruses, generating stable cell lines)
  • Practical experience with microscopy-based laboratory techniques (including immunofluorescence, chromosome breakage analysis)
  • Practical experience with recombinant protein expression and purification, Western blotting and immunoprecipitation
  • Practical experience with molecular biology (including primer design, RT-PCR, DNA/RNA isolation, cloning, DNA sequencing, expression plasmid generation, CRISPR technology)
  • Practical experience with DNA and siRNA transfection
  • Practical experience with DNA fibre analysis/DNA combing
  • Effective interpersonal and communication skills (including written and presentational)
  • The ability to work and think independently and to contribute to the planning of a programme of scientific research
  • Effective organisational skills and the ability to prioritise work to meet deadlines
  • Evidence of an ability to write to a standard required for research reports/publications
  • Willingness to work flexibly, when necessary, to fulfil the needs of the research project
  • Evidence of an ability to work individually and in a research team
  • Working knowledge of Health and Safety requirements within the laboratory setting
  • Familiarity with computer packages for data analysis
  • The ability and willingness to keep up with and have a working knowledge of the scientific literature in the field of the project
  • High level analytical capability
  • Ability to communicate complex information clearly
  • Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly.


The University is committed to safeguarding and we promote safe working practice, therefore all occupational health checks required for this role will be taken once individuals are appointed. Due to the nature of the work undertaken in this role all successful applicants will be required to complete an Occupational Health assessment once in post.

Further particulars can be found here: http://www.download.bham.ac.uk/vacancies/jd/MDSFPs.pdf

Informal enquires should be made to Prof. Grant Stewart ( g.s.stewart@bham.ac.uk )

Valuing excellence, sustaining investment

We value diversity at The University of Birmingham and welcome applications from all sections of the community

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