Scientist/Lead Discovery Biologist

West Menlo Park, California
Mar 27, 2020
Apr 12, 2020
Organization Type
Synthekine is a biotechnology company focused on discovery and developing best in class cytokine therapeutics to treat cancer and autoimmune diseases. The company was founded by Dr. Chris Garcia, Stanford University Professor and Howard Hughes Medical investigator. Synthekine is based on our unique insights on how cytokines bind to their receptors and how these systems can be tuned though ligand engineering. Synthekine was formed in 2019 and has raised its Series A venture capital round from Canaan Partners, Samsara Biocapital, and The Column Group, three leading Bay Area biotech venture funds. The company is based in Menlo Park, CA and has built integrated research, manufacturing, and in-vivo pharmacology capabilities.

Synthekine is advancing a deep pipeline that includes several preclinical programs, including biased versions of Interleukin-2 and Interferon Gamma. These cytokines have been tuned to decouple anti-cancer and anti-inflammatory activity at the molecular level, a differentiated approach to developing selective therapeutics. In addition to these pre-clinical products, Synthekine is founded on multiple therapeutic platforms, including a platform that allows for non-natural pairing of cytokine receptors, potentially resulting in novel biology and unique therapeutics.

Position Summary:

We are seeking a dedicated Scientist/Lead Discovery Biologist to join our innovative team of cytokine experts. This position will report into the Director of Cytokine Biology and will be involved in the design, generation and evaluation of novel cytokine therapeutics. The candidate is expected to be able to adjust to a flexible, dynamic and high-paced research environment with shifting priorities and deadlines.

Key Duties and Responsibilities:
  • Design and small scale expression of proteins in mammalian and bacterial systems
  • Evaluate protein function in in vitro /FACS/cell-based assays
  • Design novel functional screening assays
  • Collaborate with in vivo researchers to evaluate the therapeutic potential of engineered cytokines
  • Communicate experimental findings accurately and concisely in both oral and written form
  • Analyze, document and report laboratory data in accordance with Synthekine's standards and procedures
  • Present at group meetings, project team meetings and company-wide meetings

  • PhD with 3 years experience or Masters degree with 6 years experience or a Bachelor's degree with 10 years experience in Immunology, Cell Biology, Biochemistry or similar fields
  • Experience and knowledge of molecular biology, protein expression and an understanding of protein purification
  • An understanding of the structural underpinnings of designer cytokines
  • Expertise in the fields of immunology and/or cell biology
  • Experience using cytokines and cytokine systems a plus

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