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Senior Research Associate, Gene Therapy

Employer
Sana Biotechnology
Location
Cambridge, Massachusetts, United States
Salary
Competitive
Closing date
Oct 25, 2020

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Sector
Science, Life Sciences, Cell and Molecular Biology, Genetics
Organization Type
Corporate
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Job Details

JOB PURPOSE

Sana Biotechnology is seeking a creative and highly-motivated individual to join our Gene Therapy - Vector Design team. This individual will be responsible for advancing viral vector pipelines by generating and testing crucial research material in in vitro assays and performing IND-enabling preclinical experiments, while working closely with other members of the gene therapy and process development teams.

DUTIES AND RESPONSIBILITIES
  • Planning, designing and executing complex experiments.
  • Working with complex primary cells and analyzing them via multi-color flow cytometry.
  • Using molecular biology tools to assess the performance of new vector designs.
  • Building genetic libraries of variants, using high-throughput molecular cloning methods.
  • Optimization of viral vector production protocols, including staying up-to-date with current knowledge while driving innovation.
  • Working closely with other members of the gene therapy and process development teams to share and apply knowledge advancements.
  • Reviewing and presenting data cross-functionally at department meetings and larger forums.
  • Comply with standard laboratory practices and company policies, including strict notebook documentation and biosafety policies.
  • Contribute to the overall Sana mission and culture.

QUALIFICATIONS

Basic Qualifications
  • BS in scientific field plus 4+ years of experience, or M.S., 1-2 yrs in biotechnology, molecular biology, biochemistry, protein chemistry, virology or related discipline with 3 years of relevant industry laboratory experience, with a focus towards gene therapy and high-throughput assays.
  • Demonstrated expertise in mammalian cell line and primary cell cultures, and lentiviral vector production.
  • Experience in molecular biology, including PCR, RT-qPCR, restriction digest/ligation, Gibson/Golden Gate assembly, plasmid prep.
  • Independently and proactively able to design and execute experiments including interpreting and presenting data.
  • Excellent bench skills with attention to detail and high standards for data integrity and quality.
  • Adherence to rigorous standards of good lab practices, safety, and documentation.
  • Ability to work as part of a multi-site team.

Preferred Qualifications
  • Experience with liquid handler automation platforms (e.g. Integra, Hamilton, Tecan)
  • Experience modifying cellular genomes with CRISPR-Cas9 gene editing
  • Knowledge of multi-color flow cytometry principles and flow cytometry data analysis

WORKING CONDITIONS

This is a laboratory bench role. No regular travel required.

Company

We believe we are entering a new era of medicine.  The ability to modify genes and use cells as medicines provides new tools to meaningfully change the outcome of many human diseases.

Early pioneers have made good progress, but most of what we can deliver for patients remains in front of us. 

Sana was founded with the long view – bringing together great people and the best technologies to deliver on the challenging promise of engineered cells as medicines.

Three aspirations drive Sana as we look to treat patients with poor outcomes or currently untreatable diseases.

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