Research Fellow in Biophysical Analysis of Protein-Glycan Macromolecular Complexes

United Kingdom
£33,797 to £40,322 p.a.
Sep 30, 2020
Oct 30, 2020
Organization Type
University and College
Full Time
Are you an ambitious researcher looking for your next challenge?

Do you have an established background in biophysical techniques, and an interest in applying it to matrix biology?

Do you want to further your career in one of the UK's leading research intensive universities?

Project: Biophysical analysis of protein-glycan macromolecular complexes

The polysaccharide hyaluronan is present in all mammalian tissues dictating their elasticity, hydration, permeability and biological functions, such as in development, reproduction and inflammation. This project aims to understand how cross-linking proteins organise extracellular matrices made from hyaluronan, a process that enables these diverse functions.

You will develop and apply methods based on atomic force microscopy, and other biophysical techniques, to study the biophysical and biomechanical characteristics of hyaluronan and its cross-linking nodes at the molecular and supramolecular level. This will provide exceptional career development opportunities for the interested applicant in the emerging area of glyco-biophysics.

You must have a PhD or be close to completion in the physical or biological sciences, or a related discipline. You will be a highly motivated individual with extensive experience in the analysis of biomolecules and their interactions by atomic force microscopy and other biophysical techniques, and in working across disciplines such as soft matter physics and biology.

The work will be carried out in the multidisciplinary School of Biomedical Sciences , in collaboration with the Molecular and Nanoscale Physics Group at the School of Physics and Astronomy in Leeds.

As part of a BBSRC funded project, you will form part of a multi-disciplinary team at the Universities of Leeds (with PI Ralf Richter ) and Manchester (with PI Anthony Day ) that is internationally leading in the area of hyaluronan sciences and brings together high resolution structural and biophysical interaction analyses.

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