Postdoctoral Associate - Epitranscriptome-based diseases and enzyme targets
- Employer
- Global Academy Jobs
- Location
- Singapore
- Closing date
- Nov 7, 2020
View more
- Sector
- Science, Life Sciences, Cell and Molecular Biology
- Hours
- Full Time
- Organization Type
- University and College
- Jobseeker Type
- Academic (e.g. 'Lecturer')
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Job Details
Project Overview
The long-standing dogma in biomedical research is that genetic information in DNA is transcribed into RNA and then translated into functional proteins. This is the how of protein production. Recent research has revealed that dozens of natural chemical modifications of the nucleotide building blocks of RNA - the epitranscriptome - control when and how much protein is produced in a cell. While modifications of RNA have been known for decades, it has only recently been discovered that the patterns of epitranscriptomic marks are on-off switches for expressing 20,000 genes. Given the abundance of genetic information controlled by RNA modifications, it is not surprising that defects in their regulation have been implicated in more than 70 human diseases. This project focuses on evaluating epitranscriptome-based diseases and epitranscriptome enzyme targets against which to initiate development of novel therapeutics.
Responsibilities
The candidate will perform an evaluation of epitranscriptome-based diseases and enzyme targets to assess potential for development of novel therapeutics.
Laboratory work will involve culturing of mammalian cell lines and bacteria, possible in vivo work with small animal disease models, therapeutic target expression (protein expression and purification), and in vitro assay development.
Requirements
To apply, please visit our website at: http://smart.mit.edu/careers/career-opportunities. Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.
The long-standing dogma in biomedical research is that genetic information in DNA is transcribed into RNA and then translated into functional proteins. This is the how of protein production. Recent research has revealed that dozens of natural chemical modifications of the nucleotide building blocks of RNA - the epitranscriptome - control when and how much protein is produced in a cell. While modifications of RNA have been known for decades, it has only recently been discovered that the patterns of epitranscriptomic marks are on-off switches for expressing 20,000 genes. Given the abundance of genetic information controlled by RNA modifications, it is not surprising that defects in their regulation have been implicated in more than 70 human diseases. This project focuses on evaluating epitranscriptome-based diseases and epitranscriptome enzyme targets against which to initiate development of novel therapeutics.
Responsibilities
The candidate will perform an evaluation of epitranscriptome-based diseases and enzyme targets to assess potential for development of novel therapeutics.
Laboratory work will involve culturing of mammalian cell lines and bacteria, possible in vivo work with small animal disease models, therapeutic target expression (protein expression and purification), and in vitro assay development.
Requirements
- A Ph.D. in Biochemistry, Biology or related fields.
- Experience with proteins/enzymes (i.e. protein expression and purification)
- Good knowledge in molecular biology.
- Experience in mammalian, yeast, and bacterial cell culture.
- Experience in therapeutics development is a plus.
- Excellent tract of record in publications and scientific output.
- Independent with good analytical skills.
- Excellent communication skills (written and oral communication in English) and with co-workers from different scientific backgrounds.
- A strong interest in drug development.
- Knowledge in business development, start-up or industry experience are a plus.
To apply, please visit our website at: http://smart.mit.edu/careers/career-opportunities. Interested applicants are invited to send in their full CV/resume, cover letter and list of three references (to include reference names and contact information). We regret that only shortlisted candidates will be notified.
Company
Global Academy Jobs works with over 250 universities worldwide to promote academic mobility and international research collaboration. Global problems need international solutions. Our jobs board and emails reach the academics and researchers who can help.
"The globalisation of higher education continues apace, driving in turn the ongoing development of the global knowledge economy, striving for solutions to the world’s problems and educating a next generation of leaders and contributors."
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