A Death-Dealing Bacterial Nanomachine (P2002)

Location
Switzerland
Posted
Oct 15, 2020
Closes
Nov 13, 2020
Ref
147712
Organization Type
University and College
Hours
Full Time
100% position for 4 years, earliest starting date: 1 January 2021

The Swiss Nanoscience Institute (SNI) at the University of Basel invites highly motivated scientists to apply for the SNI PhD program in Nanoscience.

Your position

This SNI PhD fellowship will study the Type 6 secretion system (T6SS) that Gram-negative bacterial cells employ to kill other bacterial and eukaryotic cells [1] (Fig. 1). The T6SS resembles a nanoscale harpoon that is rapidly ejected from bacterial cells to deliver toxins into neighbouring cells [2,3]. In this project, we will use high-speed atomic force microscopy (HS-AFM) [4], as well as AFM force spectroscopy and confocal microscopy (CM) to study the nanomechanical forces produced by the T6SS to puncture neighboring cells. In doing so, our project promises to shed light on how bacterial cells kill their prey. You will work with a collaborative interdisciplinary team and enthusiastic mentors.

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