Scientist, Cell Differentiation

Location
Cambridge, Massachusetts, United States
Salary
Competitive
Posted
Nov 10, 2020
Closes
Dec 10, 2020
Ref
4925686002
Organization Type
Corporate
JOB PURPOSE

We are seeking a passionate and detail-oriented laboratory scientist with experience in mammalian or pluripotent stem cell culture to join a growing cell differentiation team. Under the supervision of a Senior Director, the scientist will be responsible for daily tasks involving the growth, differentiation, and characterization of pluripotent stem cells in scalable 3D differentiation models to support a cell-based therapeutic program. This role will establish the methods and parameters for scaling a cell therapeutic product to support preclinical studies, and work closely with the cell manufacturing team to adapt the methods for clinical scale.

DUTIES AND RESPONSIBILITIES
  • Culture and differentiation of pluripotent stem cells.
  • Optimization of differentiation of 3D spheroids in various suspension models to support scaling of cell therapeutic product.
  • Analysis of differentiated cell products (Flow cytometry, PCR, fluorescent microscopy, etc) and establishment of QC metrics.
  • Participate in the planning, design and execution of experiments.
  • Make observations, interpret results and document experimental methods in a well-maintained laboratory notebook.
  • Coordinate with other team members as necessary to ensure the completion of the team's research projects.
  • Comply with standard laboratory practices and company policies.

  • QUALIFICATIONS
    • BA or MS degree with 7+ years of laboratory experience, or PhD with 2+ years in a relevant scientific discipline.
    • Demonstrated expertise in 3D cell culture within scaled vessels such as spinner or shaker flasks.
    • Prior experience with mammalian cell culture is required; experience with pluripotent cell culture is preferred.
    • Ability to collaboratively work with scientists in a cross-functional or matrixed team environment.

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