Research Associate / Senior Research Associate in Smoking Studies

United Kingdom
£33,797 - £42,792
Dec 28, 2020
Jan 27, 2021
Organization Type
University and College
Full Time
The role

We have an exciting new opportunity for a talented researcher to join the CRUK Integrative Cancer Epidemiology Programme (ICEP) on a project entitled Towards improved causal evidence and enhanced prediction of cancer risk and survival at the University of Bristol to work on smoking cessation in relation to cancer risk and progression.

The postholder will be responsible for designing, planning, executing and disseminating Mendelian Randomization analyses to: i) evaluate the effects of nicotine and non-nicotine constituents of smoking on cancer incidence and cancer progression, and ii) evaluate the effect of stopping smoking on cancer progression. They will also conduct work integrating DNA methylation to investigate the potential health effects of e-cigarette use and for predicting future risk of cancer.

The postholder will have access to considerable resources, including large-scale epidemiological and molecular datasets, and advanced methodological approaches developed in Bristol, as well as the opportunity to link with Co-investigators and research colleagues as our overseas partner institutions.

The successful applicant will be based within the ICEP team and the MRC IEU within the Bristol Medical School, at the University of Bristol. They will also have strong links with the Tobacco and Alcohol Research Group (TARG) within the School of Psychological Science at the University of Bristol.

What will you be doing?
  • Conducting Mendelian randomization studies to evaluate the causal role of nicotine and non-nicotine constituents of smoking on both cancer risk and progression
  • Conducting Mendelian randomization studies to evaluate the effect of stopping smoking on cancer progression
  • Evaluating the causal role of DNA methylation in relation to cancer risk, using Mendelian randomization approaches adapted to molecular datasets
  • Coordinating the design and implementation of a study to assess DNA methylation signatures in relation to e-cigarette behaviour and constituents
  • Developing DNA methylation predictors of future cancer risk
  • Performing epigenome-wide association studies of e-cigarette behaviour
  • Feeding-forward findings for designing and evaluating interventions
  • As well as working with the team to contribute ideas, including enhancements to the technical and methodological aspects of the study, participating in workshops and dissemination activities and supporting supervision of students.

You should apply if
  • A strong track record in smoking and e-cigarette research
  • Experience in the implementation of multiple epidemiological approaches, including the application of Mendelian randomization
  • Strong quantitative research skills, including the use of statistical packages such as R
  • Experience in running research studies, including participant recruitment and primary data collection
  • Experience in the analysis of molecular data (e.g. epigenetic, transcriptomic)
  • A PhD or equivalent research experience in epidemiology, biostatistics, bioinformatics or cancer research

We strongly encourage interested applicants to make informal enquiries to Dr Rebecca Richmond;

Interviews will be held on Friday 22nd January 2021.

Additional information

Contract type: Open ended with funding until 30/09/2022

Work pattern: Full time

Grade: I/J

Salary: Grade I - £33,797 - £38,017 per annum

Grade J - £38,017 - £42,792 per annum

School/Unit: Bristol Medical School

This advert will close at 23:59 GMT on Tuesday 05th January 2021.

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.

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