Research Fellow - Chemical Biology, Diagnostics & Therapeutics

Location
United Kingdom
Salary
£30,942 to £38,017
Posted
Dec 28, 2020
Closes
Jan 27, 2021
Ref
152828
Organization Type
University and College
Hours
Full Time
You will join an international collaboration looking at the application of oligonuclkeotides (ONs) in medicinal chemistry, funded through the H2020 MSC ETN OLIGOMED. You will be based at the University of Southampton, one of the UK's top research-intensive universities. Chemistry at Southampton has a national and international reputation for excellence with world-leading facilities.

Modified ONs are considered the next generation drugs in personalised medicine. We are developing a platform technology which involves design and synthesis of modified ONs, optimisation of cell targeting and uptake, and medicinal studies in cancer, Huntingdon's Disease and cardiovascular diseases. To achieve this, we have a dedicated European network comprising of academic research teams in Southampton (lead), Stockholm, Gent, Bordeaux, Marseille, Udine and Cambridge, and includes industrial partners in London, Warsaw, Stockholm and Goteborg, as well as clinical partners in Southampton and Stockholm.

As part of this team you will develop novel DNA structures, including modifiers, that are targeting cancer cells specifically, and include the formation of bio-active secondary structures, in particular G-quadruplexes (GQ). You will work with external groups to further develop cross-linking within the GQ and conjugation with cell targeting units and evaluate their biological activity, including telomerase inhibition. Some preparation of materials using our existing procedures is also expected, and the compounds you make will be studied in a number of laboratories and facilities across the network. You will work as part of a team to ensure that materials of the required quantity and purity are produced on the timeframe needed for the biomedical investigations.

You will be skilled in practical synthetic organic chemistry and demonstrate a strong interest in working as part of a collaborative and cross-disciplinary team are required. You will have a PhD or equivalent professional qualifications and experience in synthetic chemistry with a focus on DNA chemistry. You will have strong project and time management skills to ensure we achieve the project aims and deliver the required results. You will also be involved in general running and maintenance of the laboratory and the network and are expected to adhere to our strict safety standards.

This is a full time fixed term role to start from 05/01/2021 (or as soon as possible thereafter) and ending no later than 28/02/2025 due to funding restrictions.

Equality, diversity and Inclusion is central to the ethos in Chemistry. We particularly encourage women, Black, Asian and minority ethnic (BAME), LGBT and disabled applicants to apply for this position. In recognition of our continued commitment to improving equality for women in science we were awarded an Athena SWAN Silver award in 2014 a and a second Silver award in 2017. Chemistry gives full consideration to applicants that wish to work flexibly including part-time and due consideration will be given to applicants who have taken a career break. The University has a generous maternity policy* and onsite childcare facilities. For further information please visit https://www.southampton.ac.uk/chemistry/about/Equality/index.page

The University of Southampton is in the top 1% of world universities and in the top 10 of the UK's research-intensive universities. The University of Southampton is committed to sustainability and being a globally responsible university and has recently been awarded the Platinum EcoAward. Our vision is to embed the principles of sustainability into all aspects of our individual and collective work, integrating sustainable development into our business planning, policy-making, and professional activities. This commits all of our staff and students to take responsibility for managing their activities to minimise harm to the environment, whether this is through switching off non-essential electrical equipment or using the recycling facilities.

*subject to qualifying criteria

For informal enquiries contact Dr Eugen Stulz ( est@soton.ac.uk ).

Applications for Research Fellow positions will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon successful completion of the PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.

We aim to be an equal opportunities employer and welcome applications from all sections of the community.

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