Postdoc position in Molecular Toxicology

Jan 09, 2021
Feb 08, 2021
Organization Type
University and College
Full Time
The Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences (DPhW), is offering a postdoc position to investigate the toxicological properties of oligomers present in food contact materials. The project is integrated in the Swiss Centre for Applied Human Toxicology (SCAHT) and financed for two years by the Federal Food Safety and Veterinary Office (FSVO). Further project partners are the Computational Toxicology group at the Department, the Technical University of Dresden and the Nestle Research Centre.

Project Description/Tasks:
The ToxOligo project addresses an important knowledge gap by characterizing toxicological properties of oligomers released from food contact materials (FCM) such as plastics, adhesives, printing inks and coatings. Despite known high levels in FCM, these substances are toxicologically poorly investigated, preventing adequate risk assessment.

Your position

The successful candidate will systematically review the literature and initiate expert interviews to gain insight on available knowledge of types of structures involved, exposure estimates and toxicological information. She/he will then apply in silico methods to predict physico-chemical and ADME properties, reactivity of building blocks, stability of oligomers, genotoxicity, endocrine disrupting potentials, and chronic and developmental toxicity. Additionally, she/he will establish hazard profiles for relevant selected oligomers using in vitro assays on general cytotoxicity, cellular stress pathways, neuronal cell toxicity, macrophage activation, and/or endocrine regulation. Selected FCM extracts will be considered to identify potentially hazardous materials. Together with the project partners, levels of concern will be estimated, information gaps identified, and recommendations for follow-on toxicological analyses and an evaluation concept for safety assessment of oligomers will be proposed.
Methods applied include systematic literature search, computational methods, and in vitro cell-based assays for toxicological hazard identification and characterization. The successful candidate should have a PhD with solid experience in life science methods, ideally in molecular toxicology and in vitro assays. The successful candidate will be integrated in an international research environment and is expected to contribute to the activities at the DPhW and SCAHT as well as to writing manuscripts and grant proposals. We employ a multi-disciplinary approach and look for a highly motivated, pro-active and interactive team player.

Your profile
  • PhD in the field of Life Sciences
  • Solid experience in cell biology, biochemistry and molecular biology methods
  • Ideally some experience in computational methods and in vitro assays
  • Fluent communication in English, written and oral, ideally good knowledge in German
  • Highly motivated, pro-active and interactive team player

We offer you
  • Postdoc position (available February first or upon negotiation, for two years)
  • Training into the key techniques
  • International research environment

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