Research Associate - group of Professor Peter Cullen at the University of Bristol

The role A full-time Research Associate position is available within the group of Professor Peter Cullen at the University of Bristol, U.K. Funded through a Wellcome Trust Investigator Award, you will join a team of researchers that together seek to achieve a thorough mechanistic understanding of endosomal cargo sorting in health and disease.

What will you be doing? A master conductor of endosomal cargo sorting is the retromer pathway - this orchestrates the sorting of >1,000 integral 'cargo' proteins in humans. Establishing how this pathway functions is central to understanding the evolution, organisation and activity of endosomal sorting. You will be part of a research team that seeks to address two integrated questions: · The fundamental question of how the retromer pathway is organised and integrated with other pathways to orchestrate global endosomal cargo sorting. · How understanding of retromer pathway function may provide vital insight into neurodegenerative diseases.

Specifically, you will apply an array of molecular and cellular techniques to study the fundamental question of how recognition of sorting motifs in the cytoplasmic tails of integral proteins is coupled to membrane remodelling in order to drive the formation of integral proteins-enriched membrane-bound transport carriers.

You should apply if You have a relevant PhD (or soon to be awarded) and experience in the molecular and/or cellular analysis of mammalian membrane trafficking and/or mammalian neuroscience.

Informal enquiries are welcomed, please contact Professor Pete Cullen at Pete.Cullen@bristol.ac.uk or +44 (0) 117 3312193.

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.