Research Fellow - the group of Professor Peter Cullen at the University of Bristol

The role A full-time Research Fellow position is available within the group of Professor Peter Cullen at the University of Bristol, U.K. Funded through a Wellcome Trust Investigator Award, you will be an experienced neuroscientist willing to take a senior role in a laboratory focused on achieving a thorough mechanistic understanding of endosomal cargo sorting in health and disease., including neurodegenerative disease.

What will you be doing? A master conductor of endosomal cargo sorting is the retromer pathway - this orchestrates the sorting of >1,000 integral 'cargo' proteins in humans. Establishing how this pathway functions is central to understanding the evolution, organisation and activity of endosomal sorting. You will join a research team that seeks to address two integrated questions: · The fundamental question of how the retromer pathway is organised and integrated with other pathways to orchestrate global endosomal cargo sorting. · How understanding of retromer pathway function may provide vital insight into neurodegenerative diseases.

You will combine your practical experience of neuronal cell biology with proteomic approaches developed and applied in our non-neuronal work to define retromer pathway function in primary neuronal cultures and iPSC-derived human neuronal cultures.

You should apply if

You have a relevant PhD, published experience in the analysis of complex cellular processes in mammalian neurons, and willingness to take a senior role as part of a larger research team.

Informal enquiries are welcomed, please contact Professor Pete Cullen at Pete.Cullen@bristol.ac.uk or +44 (0) 117 3312193.

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.