Principal Scientist, Biophysical Chemistry

We are currently hiring a Biophysical Chemist with objectives to contribute the development of life-saving medicines and to join fellow pharmaceutical scientists in supporting bioprocess development and product characterization by applying biophysical techniques. This position is based in Chesterfield, MO.

ROLE RESPONSIBILITIES

• Explore, develop and implementelectron microscopy (EM)technology, in particular cryo-EM, to characterize proteins, nucleic acids, polysaccharides, synthetic polymers, viral capsids, nanoparticles, etc. to support understanding the biotherapeutic products and bioprocess development.
• Apply new applications and emerging technology around advanced spectroscopy, state-of-art molecular separation techniques, and other biophysical tools.
• Interact with colleagues to provide biophysical characterization for the project teams and solve problems that contribute to process and product understanding and quality attributes.
• Excellent communication and technical writing skills, especially in composing regulatory documents.
• Use a high level of scientific judgment to adapt and create new analytical methodology and techniques by applying breadth of knowledge and prior work experience.
• Mentor and coach junior scientists.
• Identify and develop scientific activities/projects through both internal and external collaborations to support business goals.

BASIC QUALIFICATIONS

• PhD in physical biochemistry, analytical biochemistry, biochemistry, chemistry, or relate field, with 5+ years of post-doctoral and academic/industrial experience in working with biological molecules.
• Strong skills and extensive experience in cryo-EM is required. Deep knowledge around EM image analysis and modeling is also required.

PREFERRED QUALIFICATIONS

• Skills and knowledge in molecular spectroscopy such as NMR, circular dichroism, vibrational spectroscopy, light scattering, etc., is highly desired.
• Familiarity about separation technology including liquid chromatography, analytical ultracentrifugation, field flow fractionation, etc. is also desired.
• Knowledge in polymer science, pharmaceutical sciences, statistical analysis, structural biology and molecular modeling will be considered.
• Skills and experience in mass spectrometry, biological assays and other general analytical techniques is also desired.

Other Job Details:

• Last Date to Apply for Job: March 31, 2021
• Eligible for Relocation Package: YES
• Eligible for Employee Referral Bonus: YES

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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