Scientist (non-PhD), Immunosuppression

Employer
Pfizer
Location
La Jolla, California
Salary
Competitive
Posted
Feb 18, 2021
Closes
Feb 24, 2021
Ref
535971
Jobseeker Type
Professional
Organization Type
Corporate
Hours
Full Time
WHY PATIENTS NEED YOU

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire a BS/MS level Scientist for the CID Immunosuppression group.

ROLE RESPONSIBILITIES
  • Evaluation of novel mechanisms of tumor resistance to innate and adaptive immunity.
  • Execution of cell-based functional and biochemical assays to select candidate molecules for clinical development.
  • Planning and execution of ex vivo functional assessments such as multi-color flow cytometry, i mmunohistochemistry/immunofluorescence, and primary cell culture.
  • Communication of experimental results to team.


BASIC QUALIFICATIONS
  • B.S. degree with 6+ years' experience or MS (preferred) with 5+ years of experience.
  • Experience in the fields of immunology, cell biology, oncology and/or genetics.
  • Ability to plan and execute in vitro experiments with minimal supervision.
  • Expertise in standard immunologic techniques.
  • Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells, 3D spheroids, tumor explants and organoid assays that mimic human tumor microenvironment).
  • Experience with human PBMC and mammalian cell culture.
  • Experience with qRT-PCR, ELISA, MSD, ELISPOT, Nano string and cytotoxic assays.
  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic.


PREFERRED QUALIFICATIONS
  • Experience in working with biologics and small molecules for cancer immunotherapy.
  • Immune phenotyping tumor associated immune cells from primary human tumor samples by flow cytometry.
  • Experience in CRISPR technology, lentiviral transduction, tumor explant and 3D spheroid assays.


PHYSICAL/MENTAL REQUIREMENTS
  • Standing, sitting, bending, lifting, walking, and repetitive pipetting in a laboratory or vivarium setting.
  • Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory; additional PPE requirements when working in vivarium barrier suites.
  • Standard business office conditions; sitting, standing as appropriate.
  • Ability to perform mathematical calculations.
  • Ability to read, understand, and perform written protocols, and ability to perform moderately complex data analysis using Microsoft Excel, GraphPad Prism or other similar data analysis software.


NON-STANDARD WORK SCHEDULE REQUIREMENTS
  • Occasional off-hour and weekend schedule


OTHER JOB DETAILS
  • Eligible for Employee Referral Bonus


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Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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