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Senior Scientist Downstream Process Development-Conjugation

Employer
Pfizer
Location
Chesterfield, Missouri
Salary
Competitive
Closing date
Mar 9, 2021

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Sector
Science, Pharmaceutical, Supply Chain, Quality Assurance
Hours
Full Time
Organization Type
Corporate
Jobseeker Type
Professional
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

POSITION SUMMARY

A Senior Scientist position is available within the Downstream Conjugation Process Development group in Bioprocess R&D. The successful applicant will have extensive experience in laboratory research, and a desire to continue in a laboratory-focused role. The position will join a larger team of scientists focused on developing and optimizing bioconjugation, peptide, and oligonucleotide chemistry processes for biotherapeutic macromolecules for early- and late-phase clinical trials. The Senior Scientist will be responsible for working with fellow scientists to develop robust, efficient, scalable strategies for improving biochemical processes and technologies. Responsibilities will include small-scale studies, and pilot plant and manufacturing studies. Based on the analyses of these studies, the colleague will be expected to develop and test new hypotheses to improve the fundamental understanding of the chemical and biochemical processes, including organic chemistry (bio-conjugation) of large and small molecule combinations. This position will support process validation, quality by design, regulatory approaches, and quality systems.

POSITION RESPONSIBILITIES

This position requires a highly motivated individual with the ability to work closely with other members of the laboratory and the department in a matrix environment. The colleague will collaborate with the pilot plant and manufacturing staff on experimental studies, clinical manufacturing, and process validation, including work with external contract manufacturing organizations. These positions are expected to prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish externally. The Senior Scientist positions will be responsible for executing operational efficiency improvements and planning and implementing improvements across Bioprocess R&D work processes. The successful candidate must be flexible and able to support change to business infrastructure to ensure pipeline, legacy and technology success.

BASIC QUALIFICATIONS
  • Ph.D. degree with 0-4 years of experience or M.S. degree with 3-6 years of experience with a degree in a chemical, biological or engineering discipline (Organic Chemistry, Biochemistry, Biotechnology, Chemical/Biochemical Engineering or equivalent).
  • Knowledge of drug development processes for progression of biological candidates.
  • Familiarity with GLP/GMP requirements. Familiarity in scale-up and technology transfer to pilot/commercial scale.
  • Excellent oral and written communication skills.
  • The successful candidate will possess strong oral and written communication skills.
  • Strong analytical and computer skills are required.


PREFERRED QUALIFICATIONS:
  • Knowledge of synthetic chemistry route optimization.
  • Knowledge of peptide and/or oligonucleotide chemistry and synthesis.
  • Knowledge of bio-conjugation and characterization.
  • Experience with protein analytical methods (e.g. SE-HPLC, SDS-PAGE, Capillary Electrophoresis, IEF, etc.) including mass spectrometry (peptide mapping).
  • Familiarity with parenteral manufacturing requirements, including filtration, container/closure.


Other Job Details:
  • Last Date to Apply for Job:
  • Eligible for Employee Referral Bonus: YES


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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