Senior Scientist, Biochemistry

We are recruiting an experienced and highly motivated Senior Scientist/Biochemist to join the Department of Screening, Profiling & Mechanistic Biology (SPMB) at GSK's Upper Providence research facility in Collegeville, Pennsylvania. The SPMB department is committed to the discovery and mechanistic characterization of high-quality small molecule and biomolecular pre-clinical candidates. The candidate can foresee working in a highly motivating, fast-paced, collaborative and challenging research environment in which delivering a therapeutic solution to patients is the primary focus.

The SPMB department identifies and delivers high quality, biologically relevant pre-clinical leads for GSK therapeutic areas. The candidate will be expected to employ a combination of scientific tools and methodologies in lead discovery, including enzyme activity and binding assay development, ligand-target mechanism of engagement studies, high throughput screening, and compound profiling. The position requires a demonstrated working knowledge in biochemistry and enzymology; experience with techniques as they apply to protein based assay development, reaction kinetics, and mechanistic studies is highly desirable.

Key Responsibilities:

• Develop and execute target relevant, fit for purpose biochemical/enzymatic assays;
  
• Practical knowledge of quantitative characterization of enzyme-ligand interactions, experimental determination of inhibitor mechanism of action.
  
• Engage with team scientists to matrix across the discovery processes from reagent validation, assay development, hit identification, through profiling and and/or medium-high throughput screening to support early hit identification and progression of candidate quality molecules.
  
• Experience in assaying and characterizing the in vitro pharmacology of small molecules and biologics with target proteins using a variety of assay platforms.
  
• Familiarity with small molecule drug discovery, experience with enzyme based assay formats in low and/or high throughput formats is highly desired.
  
• Provide scientific and technical support for multiple project teams in diverse therapeutic areas.
  
• Must be able to work independently or collaboratively in an open lab setting.
  
• Good laboratory management; document completed lab work and results promptly, clearly, and accurately.
  
• Review literature and the findings of other researchers and attend conferences
  
• Communicate, engage, and build positive relationships with internal research partners.
  
• Analyze, interpret and present data to project team.
  
• Adapt to changing priorities.
  

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• B.Sc/M.S degree with 2 years post-degree research laboratory experience in biochemistry, enzymology, biophysics, chemistry or a related field.
  
• Experience designing, developing, and executing target relevant, fit for purpose biochemical/enzymatic assays;
  
• Experience with enzyme kinetics, quantitative characterization of enzyme-ligand interactions, experimental determination of mechanism of action.
  

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Experience in the design, development, and execution of biochemical assays characterizing the in vitro pharmacology of small molecules and biologics with target proteins using a variety of assay platforms such as absorbance, fluorescence, FRET, polarization, and mass spectrometry based detection.
  
• Experience designing and executing biochemical medium-high throughput assays in early hit discovery programs utilizing standard screening technologies.
  
• Strong computer skills, e.g. Microsoft Word, Excel, Powerpoint, data analysis software, etc.
  
• S trong interpersonal and collaboration skills; a bility to communicate results to diverse audiences
  
• Experience with biophysics assays such as microscale thermophoresis and surface plasmon resonance
  

Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

• Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk.
  
• Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  
• Continuously looking for opportunities to learn, build skills and share learning.
  
• Sustaining energy and well-being.
  
• Building strong relationships and collaboration, honest and open conversations.
  
• Budgeting and cost-consciousness.
  

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