Senior Scientist, Gene Therapy Purification Process Development

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a larger team of scientists across multiple sites focused on developing and optimizing recovery and purification processes for gene therapy vectors for early- and late-phase clinical trials. You will leverage your experience in laboratory research to develop robust, efficient, scalable strategies for improving process performance.

You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be responsible for the isolation, purification, and characterization of proteins from recombinant and natural sources. Your scientific judgment will be leveraged to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Contribute and influence at the project team level.
• Ability to troubleshoot scientific and technical challenges and contribute to their resolution.
• Develop in-process analytical methods to monitor process performance or solve process issues.
• Perform timely notebook entries and review for completed experiments.
• Satisfactorily complete all Good Laboratory Practices {part of GxP} and safety training in compliance with departmental requirements and follow appropriate safety practices in the workplace.
• Prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish externally.
• Design and execute mammalian cell culture experiments with the goal of developing robust and scalable processes for viral vectors with appropriate product quality attributes for clinical applications.

ROLE SUMMARY

A Senior Scientist position is available in the Gene Therapy Purification Process Development group, Bioprocess R&D. The successful applicant will have experience in laboratory research, and a desire to continue in a laboratory-focused role. This position will join a larger team of scientists across multiple sites focused on developing and optimizing recovery and purification processes for gene therapy vectors for early- and late-phase clinical trials. The Senior Scientist will be responsible for working with fellow scientists on technology development initiatives as well as developing robust, efficient, scalable strategies for improving process performance.

ROLE RESPONSIBILITIES

Responsibilities will include studies at wide range of scales, from high throughput/small scale to pilot/manufacturing scale. Based on the analyses of these studies, this position will be expected to develop and test new hypotheses to improve the fundamental understanding of recovery and purification processes. This position will be expected to prepare internally reviewed technical reports, make oral presentations to scientists and management, and publish externally. The Senior Scientist will be responsible for executing operational efficiency improvements and planning and implementing improvements across Bioprocess R&D work processes. The successful candidates must be able to endorse change to business infrastructure to ensure pipeline, legacy and technology success.

Qualifications

BASIC QUALIFICATIONS

• PhD with 0-3 years of experience or Master's Degree with 7+ years of experience or Bachelor's Degree with 9+ with a concentration in a biological or engineering discipline (Biotechnology, Biochemistry, Chemical/Biochemical Engineering).
• Experience in recombinant protein purification process development, technology transfer and/or bioprocess manufacturing required.
• A good understanding of protein chemistry and protein analytics, including the recent scientific literature, is required.
• The successful candidate will possess strong oral and written communication skills.
• Strong analytical and computer skills are required.

PREFERRED QUALIFICATIONS

• Diverse work experience recovering gene therapy vectors.
• Experience with high throughput technologies and Design of Experiments (DoE) is preferred.
• Experience transferring biologics processes to pilot plants or manufacturing organizations, and knowledge of data acquisition and controls systems in these environments is desirable.
• Experience taking a late-stage project through process validation and commercialization is desired.
• It would be advantageous for the successful candidate to have a strong working knowledge of the drug development process for progression of a biological candidate.

Other Job Details:

• Last Date to Apply for Job: March 10, 2021
• Eligible for Employee Referral Bonus: YES

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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