Postdoctoral Researcher - Human Genomics

University of Basel
Basel, Switzerland
Apr 11, 2021
May 11, 2021
Organization Type
University and College
Full Time
The research group "Human Genomics" at the Department of Biomedicine of the University of Basel and the University Hospital Basel (head: Prof. Sven Cichon) invites applications for a Postdoctoral researcher.

The Postdoc position will be based in the multidisciplinary, multicenter research project "Towards a mechanistic understanding of common and rare genetic risk variants for bipolar disorder: studies in iPSC models and extended families", which is funded by the Swiss National Science Foundation (SNSF) and the German Research Foundation (DFG). The project aims to improve understanding of the molecular basis of bipolar disorder. The successful candidate will apply bioinformatical and biostatistical genome analysis methods on short-read and long-read NGS sequencing data, as well as transcriptomic and cellular data.

The research group "Human Genomics" offers an excellent multidisciplinary team-oriented research environment and opportunities for training and individual career development. The research group is part of the Department of Biomedicine which unites the biomedical laboratory research of the Faculty of Medicine. The primary focus of the research group "Human Genomics" is the investigation of the molecular cause(s) of hereditary human diseases, with a special focus on complex, neuropsychiatric diseases and other brain phenotypes. To this end, we combine clinical information, human genetic knowledge, the latest technologies for genome research, and bioinformatics and -statistical approaches. Our research aims to contribute to a better understanding of the biological basis of diseases, to improve diagnosis and to provide new concepts for therapies.

Your position
  • Characterization and functional interpretation of molecular genetic and transcriptomic (expression and small RNA profiling) data
  • Performance of advanced bioinformatics- and biostatistical analyses
  • Management and analysis of genotype and next-generation sequencing data (e.g., data mining, application and interpretation of polygenic risk scores, gene-based tests, gene-set enrichment, pathway and network analyses)
  • Follow-up of relevant findings

Your profile
  • PhD in Molecular Biology, Biomedical Sciences or a related subject
  • Strong interest in human genetics and complex diseases
  • Experience in the use of computational tools (Linux, R or similar, MS Office, MS Windows) as well as applied data analysis and database usage
  • Eager to work in a modern laboratory environment and to apply cutting-edge genomic and molecular biology technologies
  • Independent worker and being a team player in a research group

We offer you
  • A responsible and versatile job in a research-oriented team with state-of-the-art laboratory equipment
  • A position, which is initially limited to three years with the possibility of extension, in a very good working atmosphere
  • Support by the team and the research group leader

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