Research Associate - EPICut project

University of Bristol
Bristol, United Kingdom
£33,797 - £38,017
Mar 26, 2021
Apr 13, 2021
Organization Type
University and College
Full Time
The role

EPICut project: A postdoc position is available with Prof. Mark Szczelkun in the School of Biochemistry as part of a prestigious ERC advanced grant. The ambition of the EPICut project is to understand the structural and mechanistic basis for how a diverse set of prokaryotic Type IV restriction systems cleave epigenetic modifications on mobile genetic elements such as phage.

What will you be doing?

We are looking for a talented and enthusiastic individual who can use protein biochemistry, biophysical assays, gel-based assays and/or single molecule techniques to investigate the mechanisms of modified DNA recognition and cleavage. You will join an established and well-funded research lab in the DNA-Protein Interactions Unit, with access to biophysical equipment including stopped flow, ITC, etc, as well as TIRF, optical tweezers and magnetic tweezers microscopes. The role will involve the day-to-day project management, collaborations with other members of the EPICut project (a PDRA and technician in Bristol, and a PDRA in Exeter), and assisting with training and supervision of postgraduate/undergraduate students.

Lab details and publications:

You should apply if

A PhD in protein biochemistry, biophysics, or a related subject is essential (awarded or imminent). Previous experience of the following is desirable, but training can be provided: analysis of protein-DNA interactions; enzymology; single-molecule microscopy; construction of microscopes. You will be highly organised, and eager to learn new skills and to interact with a broad range of colleagues.

For informal enquiries please contact Professor Mark Szczelkun, tel: +44 (0)7800 927 578, email: .

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.

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