Research Fellow in Cancer Molecular Biology

University of Leeds
Leeds, United Kingdom
£33,797 to £40,322 p.a.
Mar 28, 2021
Apr 21, 2021
Organization Type
University and College
Full Time
Are you an ambitious researcher looking for your next challenge?

Do you have an established background in understanding the molecular basis of cancer?

Do you want to further your career in one of the UK's leading research-intensive Universities?

V(D)J recombination is vital to generate a diverse antibody repertoire but since this reaction involves the breakage and rejoining of DNA, it also poses a major risk to genome instability. Recently, we found a new way in which V(D)J recombination triggers genome instability: The by-products of recombination associate with the recombinase enzymes to trigger double-strand breaks throughout lymphocyte genomes in a reaction we called cut-and-run. Notably, these breaks colocalise with those found in Acute Lymphoblastic Leukaemia (ALL) patients (Kirkham et al. Molecular Cell, 2019). Our previous studies analysed the DNA breaks in ALLs with a good prognosis. This project, funded by the Little Princess Trust, will extend these studies to test if cut-and-run also triggers genome instability in ALLs with a poor prognosis. It will use intricate molecular biology, cell biology and bioinformatics techniques to determine the cut-and-run breaks genome-wide. It will further analyse limited amounts of clinical samples to determine if the levels of the recombination by-product and/or recombinase influence the prognosis of Acute Lymphoblastic Leukaemia. In the longer term, it is hoped these studies will contribute to developing ways of blocking the dangers posed by the recombinase/by-product complex. To increase the chances of success of this short-term project, candidates with an intricate knowledge of V(D)J recombination will be preferred.

You should have a PhD (or close to completion) in Molecular Biology, Biochemistry or closely allied discipline. Experience in molecular biology, bioinformatics and the ability to produce high quality data using highly intricate molecular biology techniques is essential.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family-friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was awarded a Silver award in 2020. We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.

To explore the post further or for any queries you may have, please contact:

Dr. Joan Boyes , Associate Professor

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