Post Doc Research Fellow Lab - Wu Lab

Employer
University of North Dakota
Location
Grand Forks, North Dakota
Posted
Apr 15, 2021
Closes
Apr 18, 2021
Ref
a20d5a4d45e0
Organization Type
Corporate
Position Information: *Description*UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES, Department of Biomedical Sciences, Post-Doctoral Research Fellow, Position # 00015167The Wu lab investigates fundamental mechanisms of respiratory infection and immunity to help discover new regulators of disease pathogenesis and progression, ultimately revealing new targets for effective therapy of some horrible superbugs' infection. Considering bacterial/viral virulence and pathogenesis (Pseudomonas bacterium or SARS-CoV-2 virus), the lab asks how CRISPR-Cas adaptive immune systems regulate pathogen endogenous gene expression to dictate bacterial invasion and alter the host defense using a combination approach (cell biology, advanced microscopy, negative genetics, and RNA-seq).Questions regarding this recruitment can be sent to Dr. Min Wu at min.wu@und.edu*Duties & Responsibilities** A Postdoctoral Fellowship position is available at the Department of Biomedical Sciences at the University of North Dakota, School of Medicine and Health Sciences, to study the immune mechanisms required for the maintenance of immune homeostasis at the mucosal surfaces of the intestinal tract. Using a wide range of established animal models, we are trying to understand how immune responses to mucosal pathogens and during Intestinal inflammation are regulated. Our lab is interested in using state-of-the-art immunology, microbiology, single-cell analysis, molecular biology, and genomic approaches to understand the mechanisms by which immunity/inflammation is regulated at the mucosal surface of the intestine. A multidisciplinary strategy is being used in this study, which includes flow cytometry, next-generation sequencing, bioinformatics, microbiomics and in vivo functional studies involving animal models of infection/intestinal inflammation. Candidates are expected to interact with faculty, staff, and students within a larger group of researcher personnel at UND studying mucosal immunology/host-pathogen interactions.The candidate will perform laboratory-based research in this area including:* The design, implementation, analysis, and interpretation of laboratory experiments.* Assist in grant and manuscript preparation.* Help train graduate and undergraduate students.* Participate in all additional facets of the research laboratory. Candidates with considerable experience in immunology/host pathogen interactions or related fields are encouraged to apply. Experience with any of the following will be an advantage: flow cytometry, animal models of infection/inflammation, microbiomics, and advanced imaging techniques.As a postdoctoral fellow, the applicant's responsibility will perform the laboratory based top-notch research to contribute to the field of CRISPR-Cas systems. The person needs to handle modeling dynamical systems, in particular those of microbial immunity against their enemies (phages). New genes, proteins and functional roles will be discovered at regular basis. The person will also apply the results to interrogate empirical data that have been published elsewhere and/or collected by collaborators. The incumbent will: • Design complex experiments and conduct analyses of new genes for their working mechanisms in CRISPR-Cas immunity, propose new models for applying promising system to gain insights with empirical data.• Study host-pathogen interaction with gram-negative bacteria or emerging viruses such as SARS-CoV-2 with innate and adaptive immunity focus.• help prepare reports for PI, writing manuscripts for publication, and presentations for meetings, and constructing research proposals. There will be substantial opportunity to find new systems, novel molecules, and test new models for answering critically sought after questions. *Minimum Requirements** PhD in microbiology, immunology, cell biology or related field.* 2 years learning on knowledge of: microorganism pathogenesis, evolutionary models of bacterial populations; principles of statistics and bioinformatics.* 2 years experience in various biomedical lab assays: qPCR, western blotting, mutagenesis, primer design, structural modeling, immune cell culture, imaging, genome sequencing and microarray screening. * 2 years experience writing reports and presentations. * 2 years experience compiling and analyzing models and data to draw conclusions.In compliance with federal law, all persons hired will be required to verify identify and eligibility to work in the US and to complete the required employment eligibility verification form upon hire.*Preferred Qualifications** Strong research experience in the bacterial mutagenesis, molecular cloning, cell biology, and immunological methods, cell and animal infection, phage-host interaction, analysis and modeling of data from microbial adaptive immunity with CRISPR-Cas systems. * Demonstrated ability to perform high levels of research, summarize and analyze data at frequent basis, develop models of biological systems, and publish the research results high standards. * Experience with bioinformatic platforms (R language) and sequencing data analysis.* Interpreting and communicating material (verbally and in writing) into information usable by a diverse target audience. * Ability to: originate, produce, develop and independently complete complex research programs; establish collaborative and cooperative scientific relationships.*Minimum Hiring Salary/Position Classification**Position: *Post Doctoral Research Fellow-Twelve (12) month, non-tenure track, special appointment with University of North Dakota (UND) School of Medicine and Health Sciences (SMHS), Department of Biomedical Sciences.*Renumeration/Salary:* $40,000 - $45,000/year; commensurate with qualifications *Benefits*Includes single or family health care coverage (premiums paid for by the university), basic life insurance, EAP, retirement plan, tuition waiver, annual and sick leave. Optional benefits available: supplemental life, dental, vision, flexible spending account, supplemental retirement plans.*To Apply*Applicants MUST submit the following with their applications: (1) a full Curriculum Vitae that includes education or other academic appointments, complete publication record and research skills listed in detail, (2) the contact information of three references, (3) a PDF copy of the most representative publication of the applicant's previous research, and (4) a statement of research interest.Review of applications will begin on 09/14/2020. Position is open until filled. Additional InformationTo find out why living and working in Greater Grand Forks is way cooler, check out [Grand Forks is Cooler](http://www.grandforksiscooler.com/).All information listed in this position announcement will be used by Human Resources, the Hiring Department, and EO/Title IX for screening, interviewing and selection purposes.Confidentiality of Application MaterialsPursuant to NDCC 44-04-18.27, applications and any records related to the applications that identify an applicant are confidential, except records related to the finalists of the position, which are open to the public after the search committee has identified the top three finalists who will be invited to campus.EEO StatementThe University of North Dakota is an Affirmative Action/Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or other protected characteristic. Women, minorities, veterans, individuals with disabilities, and members of other underrepresented groups are especially encouraged to apply. Applicants are invited to provide information regarding their gender, race and/or ethnicity, veteran's status and disability status as part of the application process. This information will remain confidential and separate from your application.Veteran's PreferenceVeterans claiming preference must submit all proof of eligibility by the closing date. Proof of eligibility includes a DD-214 or NGB 22 and if claiming disabled status, a current letter of disability from the VA dated within the last 12 months.Clery StatementIn compliance with the Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act, the University of North Dakota publishes an Annual Security and Fire Safety Report. The report includes the university's policies, procedures, and programs concerning safety and security, as well as three years' of crime statistics for our campus. As a prospective employee, you are entitled to a copy of this report. The report and statistical data can be found online at UND.edu. You may also request a paper copy of the report from the UND Police Department located at 3851 Campus Road, Grand Forks, ND, 58202.