Senior Scientist, Crystallization Process Development

Groton, Connecticut
Apr 27, 2021
May 07, 2021
Jobseeker Type
Organization Type
Full Time
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

Role Summary

We are seeking a Senior Scientist to join Crystallization Technology as part of Chemical Research and Development (CRD) in Groton. The successful candidate will be responsible for designing and developing robust scalable Active Pharmaceutical Ingredient (API) crystallization processes for use at pilot-plant and commercial scale. They will apply chemical engineering principles, computational modeling approaches, and lab-scale experimental techniques to gain process understanding and to optimize the processes for quality, safety, efficiency, and robustness.

CRD, as part of Worldwide R&D in Pharmaceutical Sciences, is responsible for the design and development of process technology to manufacture active pharmaceutical ingredients (API). CRD scientists engage in all facets of development from small-scale synthesis in support of medicinal chemistry programs, to the development of the commercial synthetic route. CRD chemists and engineers collaborate with manufacturing specialists for API production in kilo-lab and pilot plant facilities, as well as provide support for technology transfer to Pfizer manufacturing sites and third-party facilities.

The successful candidate will support project teams in crystallization process design and development, technology transfer, and regulatory filing activities for new small molecule candidates. They will work closely with process chemistry, materials science, and drug product development colleagues to identify and optimize API target attributes. They will develop technology for clinical projects to deliver API that meets the targeted physical and chemical quality attributes by applying knowledge of crystallization and solid form science. Working as part of multidisciplinary teams, the scientist will develop robust and scalable processes suitable for transfer to a commercial manufacturing facility. The candidate will also improve capabilities of the group through the development and advancement of new technologies related to crystallization process development such as sono-crystallization, continuous crystallization, and integrated process control. They will develop and utilize computational models such as thermodynamic predictions, solid form modelling, and population balance models to facilitate design of crystallization processes. Given the dynamic team environment and fast-paced project timelines, strong interpersonal and communication skills are essential.

  • Apply crystallization process design and development fundamentals, modeling tools, and experimental skills using data-rich laboratory instrumentation to develop robust crystallization processes for API and intermediates.
  • Work at the interface with Drug Product Design, Material Sciences, Process Chemistry and Analytical Research and Development colleagues to identify the API target attribute profile and API impurity control strategy.
  • Select, develop, and apply new and existing process technologies to facilitate process design to achieve project goals.
  • Support technology transfer of drug substance processes to internal Pfizer API manufacturing facilities and external suppliers. May spend time at the PGS launch site supporting process validation and Pre-Approval Inspection (PAI) activities.
  • Contributes to the preparation of the Chemistry and Manufacturing Controls (CMC) section of the New Drug Application (NDA). Participates in data verification, PAI preparedness, and post submission query response. Collaborate and prepare internal research reports and technical presentation.
  • Champion the development of novel laboratory instrumentation and software modeling tools to improve process understanding. Leads the development and implementation of new and existing workflows and methodologies.
  • Remain current with the process engineering and chemistry literature. May collaborate and author external publications and present research at external conferences.

  • PhD in Chemical Engineering or Chemistry with 0-4 years or MS in Chemical Engineering or Chemistry with 3-6 years of relevant experience required
  • Detailed knowledge of chemistry and chemical engineering principles related to crystallization and isolation unit operations
  • Excellent interpersonal and communication skills

  • Working knowledge of distillation, solubility, crystallization, and filtration predictive tools
  • Experience with computational modelling tools such as ASPEN, Materials Studio, and DynoChem, Visimix, and COSMOTherm
  • Working knowledge of UPLC, PXRD, NMR, DSC and TGA, and microscopy.
  • Knowledge of Design Expert or JMP
  • Working knowledge and application of MatLab and Python
  • Working knowledge of application of in-situ analysis tools to process understanding including: FTIR, FBRM, UV/Vis, Raman
  • A good foundational understanding of synthetic organic chemistry


Ability to work in a laboratory environment performing experiments in a laboratory fume hood. Ability to perform complex data analysis


Some travel associated with technology transfer to CRD pilot plant and PGS new product launch site may be required.

Other Job Details:
  • Last Date to Apply for Job: May 10, 2021
  • Eligible for Relocation Package: yes
  • Eligible for Employee Referral Bonus: yes


Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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