Research Associate - nuclear actin dynamics

The role

We are looking to recruit a motivated and hardworking post-doctoral research associate to provide maternity cover (at 80% FTE) for a British Heart Foundation funded research project investigating the role of nuclear actin dynamics in the regulation of vascular cell behaviour within the department of Translational Health Sciences, University of Bristol.

What will you be doing?

Actin, once believed to be solely a constituent of the cytoplasmic cytoskeleton, is now recognized to function in the nucleus in gene transcription and chromatin remodelling This project seeks to characterise the importance of nuclear actin in mediating the anti-mitogenic effects of cAMP in vascular smooth muscle cells and how this controls vascular remodelling. As the successful candidate you will become an active member of the research team and take responsibility for designing and performing experiments and subsequent data analysis. This will require the use of a range of laboratory-based techniques to analyse cell signalling mechanisms and the regulation of gene transcription in cultured vascular smooth muscle cells.

You should apply if

• You have a PhD and ideally some post-doctoral research experience in vascular cell signalling and molecular biology
• You will ideally have expertise in a range of molecular and cellular biology techniques; including primary cell culture, quantitative RT-PCR, western blotting, gene transfer, gene silencing using siRNA, reporter gene assays, immunofluorescent staining and confocal microscopy.

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.