Senior Pathologist- Translational and Computational (Oncology R & D)

Employer
GSK
Location
Waltham, Massachusetts
Salary
Competitive
Posted
Feb 14, 2021
Closes
May 07, 2021
Ref
545066
Jobseeker Type
Professional
Organization Type
Corporate
Are you a Translational and Computational Pathologist keen to work with the AI/ML team to develop computational pathology capabilities and applications with our R & D oncology scientists? If so, the Senior Pathologist Translational and Computational is an excellent opportunity to explore.

GSK is expanding the Experimental Medicine Unit within the Oncology R & D organization and we are seeking experienced professionals to join our exciting journey. GSK Oncology has a commitment to the discovery and development of new oncology therapies with the life-changing potential of helping patients with cancer, specifically in four areas of cancer research:

•Immuno-Oncology : using the human immune system to treat cancer
• Cell/Gene Therapy: engineering human T-cells to target cancer
•Cancer Epigenetics: modulating the gene-regulatory system of the epigenome to exert anti-cancer effects
Synthetic Lethality: targeting two mechanisms at the same time which together, but not alone, have substantial effects against cancer

For more information on these areas of focus, please visit:
  • Oncology Transformation at a Glance .
  • https://www.lifescienceleader.com/doc/building-gsk-oncology-r-d-0001
  • https://us.gsk.com/en-us/careers/a-career-in-oncology/
  • 2019 Annual Report: https://www.gsk.com/en-gb/investors/corporate-reporting/annual-report-2019/


At GSK we see a world in which advanced applications of Machine Learning and AI will allow us to develop transformational medicines using the power of genetics, functional genomics and machine learning. AI will also play a role in how we diagnose and use medicines to enable everyone to do more feel better and live longer. It is an ambitious vision that will require the development of products at the cutting edge of Machine Learning and AI. For more information on AI and ML at GSK, please visit: https://www.gsk.ai/working-with-us/

GSK is seeking a translational and computational pathologist to integrate knowledge of disease mechanisms with drug mechanism of action to inform drug development. The successful candidate will work closely with research & development scientists who discover and develop drugs for the treatment of cancer and discover and develop biomarkers for pharmacodynamic assessment and patient selection for clinical trials. In addition, the successful candidate will work with the AI/ML team to develop computational pathology capabilities and applications in design, validation and construction of novel predictive algorithms based upon anatomic pathology images. The role is embedded within the Experimental Medicine Unit (EMU) in Oncology R&D and works across R&D to ensure that strategies for the treatment and cure of disease are based on accurate analysis of pathogenetic mechanisms.

Reporting to the VP Head Precision Medicine and Companion Diagnostics, key elements of the role include:
  • Provides expertise in the molecular, cellular, systems biology, and pathogenic mechanisms of disease
  • Provides pathology expertise and support for drug, biomarker and diagnostic programs in oncology
  • Applies a broad range of diagnostic modalities (anatomic and heme pathology)and translational pathology tools and technology, including assay or digital pathology image analysis algorithm development
  • In partnership with the VP of Diagnostic & Precision Medicine (DxPM) and the Biomarker Leads within the EMU will evaluate and implement novel tissue-based assays and/or analytical techniques
  • Aid in integrating data across different diagnostic platforms in partnership with DxPM team within the EMU
  • Applies special skills in anatomic and computational pathology including immunohistochemistry, multiplexed immunofluorescence; ii) Spatial or single-cell transcriptomics iii) Quantitative image analysis including artificial intelligence or machine learning, or iv) Advanced microscopy applications
  • Works with the EMU and AI/ML organization on the development of computation pathology capabilities and applications, involved in the design, validation and construction of trainingand validation data
  • Works with AI/ML organization on the multimodal integration of pathology data with medical imaging, cfDNA, and other data sources.
  • Contributes to regulatory submission documentation; Represents GSK to regulatory organizations, professional organizations; Interacts with key opinion leaders and contract research organizations (as needed)
  • Involved in the design of ethical and transparent AI/ML systems

*LI-GSK

Why you?

Minimum Qualifications:

We are seeking a professional with the following qualifications and skills to achieve our goals:
  • MD or MD/PhD, with Board Certification in Anatomic Pathology and 10+ years relevant academic and industry work experience.
  • Excellent traditional diagnostic pathology skills demonstrating a strong ability to interpret pathology data in the context of a deep understanding of molecular and cellular biology.
  • Demonstrated ability to handle several projects at any given time, to work successfully and collaboratively in teams and to communicate clearly both verbally and in writing to a variety of audiences.

Preferred Qualifications:
  • MD or MD/PhD with Board Certification in Anatomic Pathology/Clinical Pathology
  • Board Certification in Hematopathology is preferred

Why GSK?

Our values and expectationsare at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:
  • Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigor and risk
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Translating strategy into action - a compelling narrative, motivating others, setting objectives.
  • Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.
  • Leadership (expertise, self-awareness, high performance behaviors and ability to execute the assigned role) in a matrix and line environment
  • Embedding a culture of individual empowerment across the broader study team


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GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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