Senior Associate Scientist, Hit Discovery and Optimization

Groton, Connecticut
Apr 30, 2021
May 07, 2021
Jobseeker Type
Organization Type
Full Time
Role Summary

We are seeking a highly motivated analytical (bio)chemist to join the Hit Discovery & Optimization group in Groton, CT. As part of this group the successful applicant will play a key role in developing, optimizing, and supporting molecular property and biopharmaceutical screens to enable rapid decision making in support of the Worldwide Research and Development (WRD) portfolio

Role Responsibilities
  • Use a broad range of separation, spectroscopy, and analytical detection techniques (UV, MS) to meet project challenges and to deliver compound property data in support of key decision making
  • Conduct high throughput biopharmaceutical and molecular properties screens of new chemical entities in support of Drug Discovery and formulation efforts
  • Troubleshoot, modify, and optimize existing assays
  • Ability to analyze and interpret generated data and to present within working group
  • Build effective partnerships within department and with other research lines, in particular analytical, technology and pharmaceutical sciences, to develop novel assay solution
  • Use robotics and automation in the performance of screening.
  • Comply with all safety, scientific record keeping and good laboratory practices.

Basic Qualifications
  • Bachelor or Master's degree in relevant science (e.g. analytical chemistry, pharmaceutical sciences) with at least 2 years experience in industrial drug discovery setting.
  • Solid knowledge and ability to operate analytical techniques such as HPLC-MS, MS/MS, and spectroscopy
  • Experience with developing, executing, and troubleshooting plate-based molecular properties, pharmaceutical assays and instrumentation
  • Excellent computer, verbal and written communication skills
  • Experience with automation and liquid handling systems will be a plus
  • Experience with a wide variety of software and information systems (e.g. electronic lab notebooks, Empower/MassLynx/Chemstation/Leadscapeand LIMS) is a plus


The candidate is expected to do routine lab work in bioanalytical labs. Sitting, standing, lifting, bending, and walking. Ability to perform mathematical calculations and complex data analysis. A bility to lift 1 gallon reagent bottles comfortably is required.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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