PhD Studentship: Microbiota modulatory foods for improving sleep via the gut CLOCK (PROSLEEP)

University of Southampton
Southampton, United Kingdom
May 07, 2021
May 31, 2021
Organization Type
University and College
Full Time
Lead Institute / Faculty:University of Southampton / Faculty of Medicine

Main Supervisor:Professor Jonathan Swann

Other members of the supervisory team:Dr Caroline Childs, Professor Kieran Tuohy (FEM)

Amount of stipend and fees:£15,609.00 plus UK fees

Duration of the award:36 months, full-time.

Project description:

Disrupted sleep is recognised as a risk factor of poor metabolic health and cardiovascular risk. Recent research has identified an important role for the gut microbiota in regulating not just the gut CLOCK, but circadian rhythms systemically via metabolites produced within the gastrointestinal tract including GABA, short chain fatty acids, bile acids, serotonin, dopamine and vitamin B12. Moreover, many of these same metabolites regulate inflammation and cellular metabolism, two processes intricately linked to cardiovascular risk. This project will screen a panel of probiotic strains and prebiotics (n

Please contact: Professor Jonathan Swann, ">

Person Specification: Click here

An opportunity has arisen for a PhD studentship to join our laboratory in the Faculty of Medicine, School of Human Development and Health based at Southampton University Hospital Trust. The successful candidate will join a collaborative team with international reputations in the fields of gastrointestinal microbiology, metabolic phenotyping, and nutrition, including researchers from the Fondazione Edmund Mach research institute in Trento, Italy, and Optibiotix Health PLC. As part of this multidisciplinary project the student will be trained in microbiological techniques, analytical chemistry (mass spectrometry, NMR spectroscopy), and multivariate statistical analysis. The successful candidate should have experience in one or more of the following fields, analytical chemistry, bioinformatics, microbiology, biomedical sciences, nutrition, and/or chronobiology. The successful candidate will be required to perform experiments at the Fondazione Edmund Mach research institute in Trento, Italy (spanning two 6-month placements).

The successful candidate is likely to have the following qualifications:
  • A 1st or 2:1 degree in a relevant discipline and/or second degree with a related Masters

Administrative contact and how to apply:

Please complete the University's online application form, which you can find here

You should enter Professor Jonathan Swann as your proposed supervisor. To support your application provide an academic CV (including contact details of two referees), official academic transcripts and a personal statement (outlining your suitability for the studentship, what you hope to achieve from the PhD, and your research experience to date).

Informal enquiries relating to the project or candidate suitability should be directed to Professor Jonathan Swann ( ).

Interview date: 14th June 2021

We aim to be an equal opportunities employer and welcome applications from all sections of the community.

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