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Research Fellow in Computational Biophysics

Employer
University of Leeds
Location
Leeds, United Kingdom
Salary
£33,797 to £40,322 p.a.
Closing date
Jun 3, 2021

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Are you an ambitious researcher looking for your next challenge?

Do you have a background in computational biophysics or biomolecular simulations?

Do you want to further your career in one of the UK's leading research-intensive Universities?

This new and exciting position is funded by the British Heart Foundation and will enable us to extend our studies on the newly discovered Piezo1 mechanosensitive channel. Piezo1 channel is a critical mechanical sensor in endothelial cells, red blood cells, and other cell types such as cardiac fibroblasts. Mutations on Piezo1 have been shown to result in a number of cardiovascular diseases. Building a detailed molecular and dynamic understanding of Piezo1, which will complement the available structural and functional data, will fill an important gap in our understanding of the function of this biologically important channel.

You will use modelling and simulation tools to perform molecular dynamics simulations of Piezo1 channel in complex model membranes both at the coarse-grained and atomistic resolution. These simulations will enable us to answer key questions about the activation and ion permeation mechanism of Piezo1. You will work in the group of Dr Antreas Kalli at the Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), and the work will involve close and interactive collaboration with the groups of Prof. David Beech and Dr. Jian Shi (LICAMM) who will evaluate the models derived from the computational work.

To explore the post further or for any queries you may have, please contact:

Dr Antreas Kalli, University Academic Fellow, University of Leeds

Email: a.kalli@leeds.ac.uk

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