Site Name: USA - Pennsylvania - Upper Providence Posted Date: Apr 15 2021 The Investigator will be part of a drug discovery research team in Novel Human Genetics Research Unit at GSK R&D. This team focuses on the design and execution of preclinical studies to develop novel medicines for the treatment of chronic neurodegenerative diseases such as Alzheimer's, Frontotemporal Dementia (FTD), and Amyotrophic Lateral Sclerosis (ALS). In this role, the candidate will have the opportunity to be creative in conducting studies in models of neurodegeneration and neuroinflammation utilizing their expertise and experience in both in vitro and in vivo techniques. The successful candidate is one who is self- and science-driven, collaborative, and resourceful. The candidate must have a comprehensive understanding of Alzheimer's disease pathogenesis, and utilize this knowledge to establish acute mechanistic models of neurodegeneration and neuroinflammation in rodents and in cellular models. Experience in molecular biology and biochemical methods to evaluate the models is expected. The candidate will contribute to the development of PK/PD models and utilize them in target ID/validation as well as profile molecules in neuropharmacology studies for drug discovery programs. Key Accountabilities: Identify or develop relevant mechanistic in vivo rodent models and in vitro models to support preclinical drug discovery Define, design, and perform pharmacologic and/or genetic modification experiments in in vivo rodent models to validate targets and/or progress lead optimization projects for drug discovery Conduct pharmacological studies with an array of techniques including, but not limited to, stereotactic brain surgery, surgical methods to induce neurodegeneration and inflammation in the brain and spinal cord, intrathecal/ intracisternal/ intraparenchymal deliveries of genes/viruses/biologics, and biofluid and tissue sampling. Conduct molecular (RNA isolation, qPCR, gene editing), biochemical (ELISA, MSD, Quanterix, Western) as well as iPSC derived cellular (seahorse, live imaging) assessments. Independently execute laboratory experiments, conduct statistically supported data analysis, and deliver results in a timely manner to enable informed decision making Clearly record and communicate study results at internal and external meetings Commit to continual improvement by reading and applying the latest scientific literature, methodologies and technologies Comply with all standards and practices of data integrity, ethics, and safety Model GSK's values of patient-focus, respect, transparency, and integrity Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD or MD/PhD with 1-2 years' Post-Doctoral research experience in neuropharmacology or neuroscience in Alzheimer's Disease Demonstrated experience in surgical methods to model and deliver molecules, conduct neuropharmacology studies, and be proficient in biochemical and molecular biology methods for sample analysis Demonstrated experience with neurodegenerative diseases, and prior working experience with neurodegenerative or neuroinflammatory diseases (e.g., Alzheimer's disease) Experience with statistical data analysis Preferred Qualifications: If you have the following characteristics, it would be a plus: 3+ years pharmaceutical or biotechnology industry research experience working in matrixed drug discovery project teams Knowledge and work experience in FTD and ALS in addition to Alzheimer's Disease Demonstrated experience of learning agility (conceptual, technical, team work). Outstanding written and oral communication skills including a strong record of scientific publications Interest and agility (technical, conceptual) to navigate into different disease areas beyond neurodegeneration (e.g. metabolic disease) About NHG RU: The Novel Human Genetics Research Unit (NHG RU) was formed in 2019 to identify and advance novel targets with genetic association to disease on the foundational observation that targets with human genetic evidence supporting their causal role in the intended indication improves clinical success by two-fold. The NHG RU is therapeutically broad and complements other Research Units with strategic focus in immunology and oncology. The current portfolio interest includes projects focused on neurological diseases, including Alzheimer's, Parkinson's, ALS, FTD, and Pain, in addition to metabolic diseases. The mandate of NHG RU is to identify novel targets based on human genetics, develop assets for clinical studies, and perform Phase 1 first time in human and proof of mechanism studies in human clinical studies. This goal is enabled through strategic external (23andMe, UK Biobank, FinnGen, Laboratory of Genomic Research, Public-Private Consortia) and GSK-internal partnerships (Functional Genomics, AI/ML, and Medicinal Science and Technologies Groups). Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *This is a job description to aide in the job posting, but does not include all job evaluation details. *GSK-LI If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. 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