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Sr. Research Scientist I, Oncology Biomarker Sciences

Employer
Gilead Sciences, Inc.
Location
Belmont, CA
Closing date
Aug 13, 2021

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Sector
Science, Doctors, Oncology and Radiotherapy
Organization Type
Corporate
Sr. Research Scientist I, Oncology Biomarker Sciences
United States - California - Foster City

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company's five core values. That's because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

We are seeking an experienced Senior Research Scientist I for our Biomarker Sciences Department, to support the Oncology therapeutic area. The scientist will will work in a dynamic multidisciplinary matrixed team environment to generate and interpret data from translational and clinical studies.

The successful candidate will be responsible for the development and execution of biomarker strategies for programs in the field of oncology including both, focused on solid tumors. The scientist will design experiments to advance biomarker discovery efforts to impact clinical development and the research pipeline. He/she will provide expertise to discovery and development project teams to ensure access to state of the art thinking on appropriate biomarker and diagnostic technologies evaluate their scientific basis and clinical applicability, the validation status and any technical or statistical issues related to the proposed biomarker and/or diagnostic assays. This will include input on clinical protocols and associated documents and support to clinical study teams during the conduct of studies.

In addition, the scientist will direct the development, outsourcing and validation of clinically applicable biomarker assays and design, implement and oversee biomarker and diagnostic testing. The scientist will lead the biomarker data analysis together with the specific functional area representatives and in collaboration with the clinical teams. The Senior Research Scientist I will lead cross functional teams to achieve these aims.

Gilead Sciences Inc. is a highly matrixed organization and the ability to work effectively across these groups is a key attribute for this role. Experience in the analysis of multi-dimensional data sets and a strong background in cancer research is highly desirable.

Responsibilities:
  • Direct the development, outsourcing, and validation of clinically applicable biomarker assays including pharmacodynamic, predictive, prognostic, safety and other biomarkers for oncology programs
  • Manage critical components of cross-functional projects and may lead early stage biomarker teams to execute biomarker development strategies to generate, analyze, and interpret data from clinical studies
  • Contribute to clinical study teams as the biomarker expert during protocol development, study set-up and conduct
  • Establish and oversee external collaborations with key opinion leaders, academic sites, and CROs to advance our understanding of disease pathways and prognostic/predictive biomarkers
  • Collaborate with Research Biology, Clinical Research, Bioinformatics and Biostatistics functions to create synergy in developing biomarker strategies and translational approaches
  • Strong experimental background and experience in hypothesis-driven biological/translational research with demonstrated ability to execute well-designed experiments in tumor biology
  • Experience with genomic, epigenetic, gene expression, metabolomics, multiplexed protein detection or other related emerging platforms or data sets is desirable.
  • Must be able to work independently and effectively on multiple programs in a fast-paced matrixed environment
  • Excellent collaboration, communication (verbal and written), and interpersonal skills are required to engage and be productive within a high achieving team environment
  • Must be team and detail-oriented, motivated, and results focused.


Technical Skills:
  • Demonstrated expertise in oncology
  • Ability to integrate complex scientific ideas, generate testable hypotheses, and execute
  • Analysis and interpretation of biomarker data in preclinical and clinical setting
  • Broad understanding of drug discovery and development in both early and late stage
    development and familiarity with regulatory approval process.
  • Experience with the discovery, characterization, clinical validation and utilization of innovative biomarkers
  • Knowledge of biomarker discovery and development, assay development/validation, clinical discovery of biomarkers, and MoA/translational research.
  • Authoring of biomarker strategy documents, biomarker specific portion of clinical protocols, and regulatory documents
  • Basic understanding of technical aspects of companion diagnostics development
  • Proven publication record
  • Strong verbal and written communication skills
  • Understanding of IP, contracting terms and provisions


Experience:
  • PhD and/or post-doctoral training in the area of oncology or related medical science field with a minimum of 3 years of directly relevant biotechnology or pharmaceutical industry experience.
  • Candidate must be detail-oriented with excellent record keeping and organizational skills.
  • Must be a highly flexible, results oriented, independent self-starter who enjoys working in a fast paced dynamic multi-disciplinary environment.



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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'EEO is the Law' poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

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