Scientist, AAV Production

7 days left

Employer
Pfizer
Location
Cambridge, Massachusetts
Salary
Competitive
Posted
Jul 19, 2021
Closes
Aug 01, 2021
Ref
556019
Jobseeker Type
Professional
Organization Type
Corporate
Hours
Full Time
Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

ROLE SUMMARY

We are seeking a creative and motivated candidate to drive development of AAV production platform in the BioMedicine Design (BMD) line of the Medicinal Sciences Organization. The candidate will capitalize on their AAV production experience to optimize processes for the advancement of AAV expression platform in the discovery space to support the gene therapy portfolio across Pfizer.

ROLE RESPONSIBILITIES

  • Contribute to development of purification platform for novel AAV capsids
  • Oversee and support different aspects of AAV production at various scales with the focus on affinity purification
  • Collaborate with groups across Pfizer to develop processes compatible with and capitalizing on existing internal knowledge/infrastructure
  • Routinely present data packages at project meetings
  • Propose experimental designs and work with project leads, and other senior group members on identifying and advancing best strategies


Qualifications

Must-Have

  • Master's Degree with 2-4 years of experience or Bachelor's Degree with 4-6 years of experience with mammalian expression, AAV production, purification and relevant analytical methods
  • Understanding of the discovery and development of AAVs as therapeutics
  • Significant experience, knowledge and understanding of purification technologies and operations such as AKTA or automated protein purification chromatography, TFF or UF/DF, Depth filtration
  • Curiosity and passion for research with strong interest in synthetic biology and gene therapy, creative and flexible thinking
  • Excellent organization and communication skills, written and oral
  • Ability to plan, organize, problem solve (troubleshoot), design experiments, work efficiently independently and in a team


Nice-to-Have

  • Related manufacturing or process development experience in biotech industry
  • Experience with library screening


Other Job Details:
  • Last Date to Apply for Job: July 27, 2021
  • Eligible for Employee Referral: Yes


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Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

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