Principal Scientist/Associate Director, Downstream Process Development

Employer
Solid Biosciences
Location
Somerville, MA
Posted
Jul 20, 2021
Closes
Jul 22, 2021
Ref
2212078475
Sector
Science
Organization Type
Corporate
Position:

Principal Scientist/Associate Director, Downstream Process Development

Location:

Cambridge, MAJob Id:

210106

# of Openings:

1

Summary:Solid's Start: Solid is the English translation of Eytan, the Hebrew name of Solid's co-founders Ilan and Annie Ganot's son, Eytani, who was diagnosed with Duchenne muscular dystrophy (Duchenne) in 2012 at the age of 3. Unsatisfied with the existing Duchenne treatment landscape, the Ganots built a disease-focused company with the people and potential to advance innovative science quickly and responsibly.Solid's Culture: Much of what you can learn about Solid and our culture can be found in our name. We come to work each day for the Duchenne community, and that community is our family. We have a collective strength and determination that propels us to embrace innovation and challenge the status quo because central to all that we do is the unwavering commitment to advance meaningful therapies for the Duchenne community. We are a fiercely passionate and committed team, driven to collaborate with thoughtfulness and respect. We value exceptional skills, scientific curiosity, entrepreneurial spirit, diversity and adaptability. #TogetherWeAreSolid in our mission to find a cure for Duchenne muscular dystrophy and we will not stop until we've done it.Solid Biosciences is seeking an experienced Principal Scientist/Associate Director to join our Process Development team and contribute to the development of our downstream viral vector manufacturing processes. This individual will join a dynamic and motivated team to develop and characterize unit operations in support of a mid to late stage viral vector program, as well as tech transfer of the process to the clinical/commercial manufacturing team.The successful candidate will be responsible for leading a team of scientists and engineers on the design and execution of experiments supporting troubleshooting, development, characterization, scale-up, and transfer of the downstream manufacturing processes. They will also be responsible for evaluation and implementation of new and existing technology. Key Duties & Accountabilities:1. Key member of the Process Development leadership team to define development strategies and technology roadmap2. Oversight, scheduling, planning and reviewing of viral vector process development and tech transfer experiments in the PD lab related to all downstream processes and in-process analytics, to include process optimization and problem-solving processes and equipment3. Lead a team of scientists and engineers focused on development and optimization of viral vector purifications processes4. Identify, evaluate, and implement new and existing technologies to improve process efficiency, control, and understanding5. Collaborate & coordinate with other groups within the organization on multiple projects simultaneously6. Apply DOE and other advanced statistical techniques to design experiments related to process development, characterization, and scale-up7. Authoring of high-quality documents, including technical reports, SOPs, experimental protocols, and regulatory filings8. Prepare high quality presentations for communication at cross-functional meetings and to senior leadership teams9. Develops and mentor direct reports through challenging assignments and providing constructive feedback, goal setting and monitoring performance on a routine and ensuring that overall project goals are on trackCompetencies Required:LeadershipCritical ThinkingAnalytical ThinkingAttention to DetailInnovationKnowledge: Education, Experience, & Skills:Ph.D. in Chemical Engineering or related field and 6+ years of experience, Master's or a Bachelor's degree in the same field with 10+ years of experience in downstream process developmentLeadership experience with proven capability as a successful leader in a strategic multifunctional environment, highly skilled in leading change and people agilityStrong scientific skills and process development experience working with gene therapy productsProven expertise in all downstream purification concepts including chromatographic separation, centrifugation, filtration, and viral inactivation/removalExcellent technical, organizational, interpersonal, collaborative, and verbal/written communication skills - including excellent presentation skills and the ability to communicate with employees at all levels including senior managementStrong understanding of GxPs, process characterization, and technology transferAbility to manage, analyze, and interpret complex experimental dataAbility to apply engineering fundamentals to process design and scale-upAbility to apply statistical tools for process monitoring, experimental design, and data analysisTravel Commitment:Some travel may be required.
Apply for this Position

Similar jobs

More searches like this

Similar jobs