Director, Protein Engineering

4 days left

Employer
Mosaic Biosciences, Inc.
Location
Boulder, CO
Posted
Jul 26, 2021
Closes
Aug 08, 2021
Ref
2329681193
Sector
Other
Organization Type
Corporate
Mosaic Biosciences is seeking an experienced and creative expert in protein/antibody engineering who will drive the advancement of novel therapeutics. The candidate will mentor protein therapeutic-focused scientists, lead a protein therapeutic project team(s), consisting of protein engineers, biochemists, molecular and cellular biologists, and protein-production scientists. Candidate will utilize cutting edge biochemical, biophysical, and cellular assays, as well as develop new technologies to move therapeutic projects forward.

Responsibilities
  • Lead a high performing team of protein/antibody engineers with varied specialty areas including MOA elucidation, computational biology, display technologies, immunization campaigns, protein expression and purification, protein chemistry/conjugation, and analytical, biochemical, and cellular assays.
  • Lead discovery differentiated lead molecules including but not limited to antibodies, multi-specifics, cytokines, fusion proteins, and proteases.
  • Lead discovery differentiated lead molecules including but not limited to antibodies, multi-specifics, cytokines, fusion proteins, and proteases.
  • Mentor and provide scientific leadership, strategic and technical guidance to our growing team of scientists.
  • Responsible for developing new technologies and platforms to stay at the cutting edge of biologics discovery.
  • Drive lead optimization strategies towards optimal developability criteria.
  • Generate tools to participate in target discovery/validation activities.


Qualifications:
  • Ph.D. and postdoctoral work in Biochemistry, Immunology, Molecular & Cell Biology or similar fields with 10+ years of industry experience.
  • Extensive experience in engineering and characterization of protein and antibody variants as preclinical leads and development candidates.
  • Ability to lead a high performing multidisciplinary biologics drug discovery team.
  • Expertise in biology, immunology, and biochemistry to design and implement functional and cell-based assays to support technology development, antibody selections, and mechanistic studies is desirable.
  • Experience leading and mentoring a team of scientists. Experience in leading complex multi-disciplinary drug discovery programs.
  • Experience with various display technologies (yeast, phage, mammalian). Experience and knowledge of molecular biology, protein expression, purification and characterization.
  • Excellent written, oral, and organizational skills.

Similar jobs

More searches like this

Similar jobs