Scientist - SAM
Site Name: USA - Maryland - Rockville Posted Date: Jun 25 2021 Are you motivated by a challenging role in biology, where scientific demand is driving team growth? If so, this Scientist role would be a great opportunity to consider. As a Scientist in the Structural Biology Lab in the Preclinical Department of GSK Vaccines (Rockville, Maryland), you will be responsible for 3D structural characterization and analysis of candidate vaccine antigens and antibodies. This group plays an essential role in supporting preclinical, development and life-cycle management projects at GSK Vaccines. We are looking for a highly motivated scientist, with a proven track record in the most relevant areas of x-ray crystallography, high throughput screening, protein expression, protein biochemistry, and protein engineering, in order to provide expertise in vaccine development for GSK projects. As a Scientist, you will be contributing to various studies and be responsible for delivering pre-clinical and clinical data analysis. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following… 3D structural characterization and analysis of candidate vaccine antigens and antibodies. Supporting preclinical, development and life-cycle management projects at GSK Vaccines. X-ray crystallography, high throughput screening, protein expression, protein biochemistry, and protein engineering, Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Degree in structural biology, biochemistry, biotechnology or related field. PhD with 0-2+ years of experience, MS with 5+ years of experience, or BS degree with 10+ years of experience. Experience in protein x-ray crystallography, including high throughput crystal screening and crystal optimization. Proficient with crystallography software for data processing and visualization (HKL, Phenix, XDS, Coot, Pymol, Chimera, CCP4). Experience with diverse protein purification methods (e.g. affinity column purification and size exclusion chromatography) and equipment (e.g. AKTA avant systems). Experience with bioanalytical and biophysical assays (e.g. SDS-PAGE, Western blot, SPR, DSF, DLS). Preferred Qualifications: If you have the following characteristics, it would be a plus: PhD degree with focus on x-ray structural analysis of antigen-antibody complexes. Familiar with complimentary techniques such as negative stain and cryo-electron microscopy. Experience with protein engineering and design software (e.g. Rosetta, MOE). Experience with purification and characterization of RNA. Experience in high throughput protein purification from mammalian cells. Be a self-starter able to handle multiple projects concurrently. Good knowledge and understanding of GSK Vaccines strategy and objectives, regulatory, requirements, as well as competition intelligence and intellectual property aspects. Ability to integrate this knowledge in decisions and recommendations. Excellent communication skills, ability to effectively collaborate within multiple project workstreams. Strong track-record of scientific publications in peer-reviewed journals, with at least 1 first author research manuscript. Fluency in English, spoken and written. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *This is a job description to aide in the job posting, but does not include all job evaluation details. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). 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