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Postdoctoral Fellow - Tumor Immunology

Employer
City of Hope
Location
Bradbury, CA
Closing date
Nov 12, 2021

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Sector
Doctors, Allergy/Immunology
Organization Type
Corporate
Dr. McGee's laboratory seeks a post-doctoral researcher interested in tumor immunology and studying the immune response to radiation in multiple cancer types, including liver cancer (hepatocellular carcinoma), colorectal cancer, pancreatic cancer and lung cancer. Dr. McGee completed her Ph.D. in the laboratory of Dr. Richard Flavell at Yale University and developed an IL-22-IRES-sgBFP mouse model that can be used to visualize IL-22 in vivo in response to various inflammatory stimuli, including ischemia/reperfusion injury in the liver, inflammation-associated colorectal cancer, and IL-23-mediated skin inflammation/psoriasis. She worked with Dr. Flavell and others to discover a role for IL-22 in skin wound repair and identified that IL-22 acts on fibroblasts to increase the expression of fibronectin and collagen, while promoting the differentiation of fibroblasts to myofibroblasts. More recently, she worked with colleagues at UC Davis to characterize unique aspects of the peripheral immune after radiation to different organs, include a decrease in cytotoxic NK cells and an increase in TIM3+ NK cells. During her post-doctoral training at the Salk Institute, she has developed techniques to identify neoantigen-specific T cells in patients with NSCLC. Her lab at City of Hope is focused on studying the role of radiation-induced cell death mechanisms in the activation of innate lymphoid cells (ILCs) in various tumor microenvironments. The research spans the entire spectrum from cell culture to murine models (e.g. transgenic mouse models and knock-in reporter mice) to patient samples.

The long-term goals of the McGee lab are to identify key molecular and immunologic pathways that can be targeted to enhance the immune response to radiation and develop personalized medicine approaches for cancer patients treated with radiation. Her lab is dedicated to translational research and utilizes both cancer models and patient tissues to test novel insights from the clinic using a "bench-to-bedside" strategy.

Basic education, experience and skills required for consideration:

A Ph.D. degree in life or biomedical sciences, immunology or a related discipline is required. Candidates with an M.D. and significant research experience will be considered.
Proficiency in immunology, molecular and cellular biology, cancer biology and/or animal (mouse) studies is required.
A desire to work in a collaborative, interdisciplinary lab environment that values communication, initiative, professionalism, and teamwork is required.

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