Postdoctoral Fellow - Computational Biology

The Wang Laboratory at the Department of Systems Biology, Beckman Research Institute, City of Hope, is seeking for a talented and motivated Postdoctoral Fellow to lead the project for RNA splicing dysregulation and oncogenesis in blood malignancies. Candidates with strong background in computational analysis of large dataset, RNA metabolism and cancer biology, are encouraged to apply. Wang Laboratory is currently funded by two R01 grants, foundation grants, and City of Hope Startup package.

Lab Publications:

Yin SY, Gambe R, Brooks AN, Sun J, Fan J, Seiler M, Obeng E, Zhang W, Wan Y, Cibulskis CL, Neuberg D, Buonamici S, Smith PG, Campagna D, Meyerson MM, Fleming MD, Ebert BJ, Carrasco RD, Wu CJ, Wang L. A murine model of chronic lymphocytic leukemia based on B cell-restricted expression of Sf3b1 mutation and Atm deletion. Cancer Cell. 2019, 35: 283-296

Wang L, Brooks AL, Fan J, Wan Y, Gambe R, Li S, Hergert S, Freeman SS, Levin JZ, Fan L, Seiler M, Buonamici S, Smith PG, Chau KF, Cibulskis CL, Zhang W, Rassent LZ, Ghia EM, Kipps TJ, Fernandes S, Bloch DB, Kotliar D, Landau DA, Shukla S, Aster JC, Reed R, DeLuca DS, Brown JR, Neuberg D, Getz G, Livak KJ, Meyerson MM, Kharchenko PV, Wu CJ. Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia. Cancer Cell. 2016 30(5): 750-763. PMC5127278

Wang L, Fan J, Francis J, Zhang C, Herger S, Gambe R, Li S, Zhou C, Yang C, Xiao S, Dal Cin P, Bowden M, Kotliar D, Shukla S, Brown JR, Neuberg D, Livak KJ, Kharchenko PV, Wu CJ. Integrated single-cell genetic and transcriptional analysis suggests novel drivers of chronic lymphocytic leukemia. Genome Res 2017 27 1-13

Basic education, experience and skills required for consideration:

A Ph.D. degree in systems biology, molecular biology, cancer biology, or a related discipline is required
Understanding fundamental mechanism of RNA splicing is preferred
Knowledge in large DNA and RNA dataset analysis is preferred
Excellent verbal and written communication skills
Self-motivated, independent and creative