Gilead Sciences, Inc. is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, serious respiratory and cardiovascular conditions, cancer and inflammation, headquartered in Foster City, California.
Gilead's core values of integrity, inclusion, teamwork, excellence, and accountability shape our culture and are the foundation of our future success. Challenge yourself and make a difference in the world - Being Here Matters.
The primary responsibility of this Drug Metabolism and Pharmacokinetic (DMPK) scientist is to serve as a DMPK representative and lead a group to investigate the intracellular metabolism and transport of nucleoside analogs. This job role will focus on providing guidance to drug discovery project teams, defining candidate selection strategies, and continue through drug development phases to registration/post approval.
Essential Duties and Job Responsibilities:
Work closely with internal and external resources to assure high quality and timely delivery of nonclinical and clinical PK-ADME data for molecules in discovery and development.
Design and perform complex analysis to characterize intracellular metabolism, transport and disposition of nucleoside analog drugs.
Serve as DMPK subject matter expert on dynamic cross-functional teams, provide in vitro and in vivo drug disposition data, interpretation and presentations to teams.
Able to communicate and educate others on complex areas of PK-ADME as a technical expert.
Supervising associate and research scientists may be needed.
Make major contributions to scientific literature and conferences through publication and presentation of research results.
Knowledge, Experience and Skills:
Requires a highly motivated individual with a PhD degree in biology, biochemistry, pharmaceutical sciences or related area with 10+ years of industry experience.
Prior experience contributing to the discovery and development of drug candidates from preclinical through clinical trials.
Be a subject matter expert in cellular uptake intracellular metabolism, elimination, human dose projection and metabolite identification of nucleoside analog drugs demonstrated through presentation/publication record.
Provide oversight and integration of the data and data-reports, proactively manage to resolve data gaps, and address regulatory inquiries.
Comfortable working with and educating colleagues in drug metabolism, toxicology and clinical pharmacology on strategies to understand the PK-ADME.
Demonstrates excellent scientific verbal, technical communication and interpersonal skills. Must be organized, pay attention to details and have strong planning skills.