Sr Associate Scientist, Biologics Discovery

Employer
Gilead Sciences
Location
Belmont, CA
Closing date
Sep 30, 2021

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Sector
Science
Job Description
Gilead is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world.

Specific Responsibilities:

The Biologics Discovery group is a specialized team within the Protein Therapeutics function that is responsible for the discovery and optimization of biologic drug candidates. We seek a highly motivated Senior Associate Scientist to join this team in a newly created position. The successful candidate will use single B-cell technologies to enable antibody discovery in support of all therapeutic areas at Gilead. The candidate will also work on cross-functional teams and be a part of a functional area specializing in the discovery and screening of novel biologic modalities across several therapeutic areas.

Essential Duties and Job Functions:

In this laboratory-based role, the successful candidate will support efforts to generate novel antibody-based therapeutics through single B-cell technologies. They should have knowledge of antibody structure and function with experience in antibody discovery technologies, molecular biology, cell culture, and basic characterization assays. Additional job requirements:

Work cross-functionally and across therapeutic areas to carry out rodent B-cell isolation, antibody molecular cloning and reformatting, and initial characterization
Interact and collaborate with Protein Therapeutics and Data Science colleagues to support NGS-based antibody discovery and optimization efforts
Independently design, analyze and interpret experiments to characterize the binding and functional properties of novel antibodies
Deliver scientific presentations in lab and project team meetings
Maintain familiarity with relevant scientific literature
Knowledge, Experience and Skills:

M.S./B.S. in biological sciences, preferably with at least 14 years of relevant professional experience and a proven track record of successful antibody discovery. Job title is flexible based on experience. An ideal candidate will have experience in most of the following areas:

Hands-on experience in antibody discovery and development methods
Experience with molecular biology and cloning
Experience with biochemical assays and quantitative analysis of protein-protein binding interactions (e.g. FACS, ELISA, Octet, etc.)
Experience with single-cell FACS sorting highly desired
Mammalian cell culture and transient protein expression experience is a plus
Knowledge of antibody structure/function relationships is a plus
Prior experience with antibody sequence analysis from discovery campaigns is a plus
Experience with high-throughput liquid handling systems is a plus (e.g. Biomek, Hamilton, etc.)
Laboratory animal handling and immunization experience is a plus

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