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Postdoctoral Research Associate Macromolecular Crystallography

Employer
Brookhaven National Laboratory
Location
Precept, NE
Closing date
Oct 22, 2021
Position Description

The Center for BioMolecular Structure at the National Synchrotron Light Source-II (NSLS-II) at Brookhaven National Laboratory seeks a postdoctoral research associate to join our program that operates two state-of-the-art macromolecular crystallography (MX) beamlines, a life-sciences scattering beamline, and a cryo-EM facility. The successful researcher who joins our multi-national multi-disciplinary team will expand the scientific capabilities of the Frontier Macromolecular Crystallography (FMX) beamline's unsurpassed brightness and micro-focus beam. The project will establish room temperature and time-resolved serial synchrotron crystallography at the FMX beamline, in a close collaboration with our colleagues at the BNL Biology department, with the goal to study dynamic processes in proteins such as enzymatic reactions. The position is a two-year term appointment.

Essential Duties and Responsibilities:

Study dynamic and time resolved processes in proteins with a fixed-target chip-scanning goniometer at FMX.
Develop a fixed-target sample holder, room temperature sample handling protocols and a reaction trigger mechanism.
Design the time-resolved serial synchrotron crystallography (SSX) experiment and associated data analysis.
Successful structure solutions of reaction intermediates will provide new insights into protein function.

Position Requirements

Required Knowledge, Skills, and Abilities:
Ph.D. in chemistry, biochemistry, physics, biophysics, or a related field
Demonstrated background in Macromolecular Crystallography data acquisition and analysis
Demonstrated publication record in X-ray or neutron-based research
Excellent oral and written communication skills and effective interaction in a team environment

Preferred Knowledge, Skills, and Abilities:
Experience in the use of synchrotron beamlines for structural biology
Experience in protein purification and sample preparation for structural analysis
Interest or skills in instrument development, particularly in liquid handling
Experience with programming
Experience in scientific computation and large-scale data processing

BNL policy requires that research associate appointments be made to individuals who have received their doctorate within the past five years .

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