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Staff Scientist I - Neural Plasticity

Lieber Institute Inc
Baltimore County, MD
Closing date
Sep 19, 2021

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Job Description

A little about us:

The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with developmental brain disorders. We are one of the only research institutions in the world focused specifically on understanding how genes and the environment influence the way our brains develop that lead to conditions such as schizophrenia, autism, bipolar disorder and related developmental brain disorders. Through our cutting-edge research, answers are emerging and being translated into a robust pipeline of new drugs in development. And, by focusing on genes and their dynamic interplay with the environment, we are getting even closer to the holy grail in medical research, the discovery of strategies for primary prevention.

We are a group of dedicated, multidisciplinary and optimistic researchers, working at the cutting edge of science, utilizing state-of-the-art tools to unlock the mystery of the brain and transform the way we approach the development of new treatments, and ultimately cures. LIBD is an independent 501(c)(3) medical research institute located in the Bioscience Park on the campus of the Johns Hopkins School of Medicine and Hospital in Baltimore, MD.

Job Summary:

We are seeking a self-motivated individual to join our research group as a Staff Scientist. This position will help lead key components of several large-scale spatial and single-cell transcriptomics projects in postmortem human brain tissue across multiple neurodevelopmental and neuropsychiatric disorders. Candidates must hold at least a master's degree in neuroscience, biology or a related field with extensive full-time experience (PhD with relevant postdoctoral experience is preferred). Previous bench experience in molecular/cellular biology, confocal microscopy, and/or next generation sequencing is required. Expertise and knowledge in human neuroanatomy as well as experience handling postmortem human brain tissue is strongly preferred. The applicant will be expected to organize experimental workflows for the team on these large scale, high-throughput projects. They will be required to design, coordinate, and conduct bench experiments, as well as participate in data analysis working in collaboration with data scientists. Ability to perform work efficiently and carefully are essential. The position will be required to train, supervise and organize the work of research assistants and technicians. Given the multi-disciplinary and team science nature of the projects, the position requires highly effective communication with teams leading the neuropathological and computational aspects of the project.

Key responsibilities:

· Assisting with human brain tissue dissections

· Preparation and cryosection of human brain tissue

· RNA-seq library construction

· Nuclei isolation and FACs sorting

· Immunohistochemistry and histological staining

· Confocal imaging and slide-scanning

· Other duties as assigned

EEOC Statement: At the Lieber Institute, we are committed to a work environment of mutual respect where employment decisions are based on merit. As an equal opportunity employer, the Lieber Institute does not discriminate in employment opportunities on the basis of race, color, religion, color, sex, gender identity/expression, sexual orientation, pregnancy, marital status, age, national origin or ancestry, citizenship, disability (physical or mental), genetic information, military service, or other non-merit based factors protected by state or federal law or local ordinance, with regard to any position or employment for which the applicant or employee is qualified.

Minimum Qualifications:

· Master's degree in neuroscience, biology or a closely related field is required, as well as a minimum of five years related laboratory research.

· PhD in neuroscience, biology or a closely related field is preferred.

· Excellent organizational, communication, and teamwork skills

· Excellent time management skills with ability to efficiently organize experiments to deliver experimental results on tight deadlines

Special Knowledge, Skills, and Abilities:

Expertise with these topics, familiarity with these techniques or data analysis skills are preferred:

· Cryosectioning

· Human neuroanatomy

· Single cell RNA-sequencing platforms

· Image processing analysis in Python and/or Matlab

· Gene expression analysis in R/Bioconductor

Physical Requirements:

- Remaining in a seated or standing position for extended periods of time;

- Reaching and grasping to manipulate objects with fingers;

- Mobility, including the ability to maneuver around a laboratory setting including the ability to move materials weighing up to 25 pounds;

- Communication skills using the spoken and written word;

- Having the ability to receive detailed information through oral communication;

- All other physical demands in a standard laboratory environment.

** If accommodations are needed due to pregnancy or a disability, please contact
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