Site Name: UK - Hertfordshire - Stevenage, USA - Pennsylvania - Upper Providence Posted Date: Sep 8 2021 Are you energized by the challenge of shaping and accelerating the scientific expertise of a biology program? If so, this Investigator, Immuno-Oncology opportunity could be an exciting opportunity to consider. The Immuno-Oncology & Combinations Research Unit (IOC RU) is seeking a highly motivated scientist with expertise in B cell immunology to join the team as an Investigator. The successful candidate will design, lead and deliver biological work packages to support the identification, validation and progression of novel targets. As a strong lab-based immunologist, you will be responsible for leading, designing and executing on immune cell-based assays that recapitulate disease-relevant biology, with a particular focus on targets that modulate the role of B cells in tumors. The successful candidate will also perform small scale CRISPR/Cas9 editing in primary immune cells and cell lines to answer key biological questions and validate novel targets. This is an exciting role that will allow the successful candidate to have a critical contribution to our efforts to identify novel drug target opportunities for immuno-oncology at GSK. The Investigator will need to be a creative, innovative self-starter, with excellent verbal and written communication skills, and a desire to lead from the lab. You will be accountable for generating high quality, robust data and must have an ability to work effectively both independently and as part of a multidisciplinary matrix team. Additionally, the successful candidate will need to be proactive, open to the ideas of others and have a deep curiosity and enthusiasm for learning novel approaches and techniques. Please use the cover letter to highlight how you meet the competencies for the role. Your cover letter along with your CV will be used to assess your application. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: PhD (or equivalent experience) in immunology. 3+ years' experience in the field of immunology/immuno-oncology, with a focus in B cell biology. Immune cell assay development experience. Expertise in characterizing immune cell function by phenotypic and functional assays, such as multi-color flow cytometry. Preferred Qualifications: If you have the following characteristics, it would be a plus: Prior experience leading target validation and/or therapeutic programmes in the B cell space. Track record of independent thinking and problem-solving. Strong communication skills. Ability to lead from the bench and to work in a team to achieve group objectives. Experience of small-scale gene editing/gene silencing/transfections (e.g. nucleofection) in primary immune cells. Bioinformatics experience e.g. interrogating scRNAseq datasets. Experience of using CRISPR/Cas9 for gene editing would be advantageous. Experience of matrix supervision of more junior scientists. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *This is a job description to aide in the job posting, but does not include all job evaluation details. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.