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Investigator, Structure and Function Characterization

Collegeville, Pennsylvania
Closing date
Sep 21, 2021

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Site Name: USA - Pennsylvania - Upper Providence Posted Date: Jul 14 2021 This role will be responsible for working within a team of bio-analysts to design and develop cell-based reporter assay capable of simultaneously measuring the potency of more than one drug or Mechanism of Action in a single assay. Key responsibilities: Automate, qualify and validate cell-based reporter assays in a GMP environment and their use in the release of pre-clinical, clinical, and commercial drug supplies. Contribute to the management of the bioassay's life-cycle strategy. Ensure team's scientific studies are recorded and documented both accurately and coherently. Manage the successful and timely transfer of analytical technologies to and from contract manufacturers, testing labs, or the GSK Manufacturing organization. Some travel may be involved. Provide scientific leadership to method development and have a solid understanding of biopharm product Mechanism of Action(s) Develop and maintain collaborative relationships with groups outside of biopharm analytical sciences and GSK. Seek all opportunities to develop and maintain a strong IP position. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: BSc / MSc /PhD with 10, 5- or 1-year(s) relevant post graduate experience in Cell biology, Biochemistry, Physiology, Immunology or related discipline. Experience with the design and development of reporter-based assays (could include the development of high throughput assays) using luciferase or other similar systems to measure the response in cell systems. Experience with solving problems and analyzing data related to the drugs' Mechanism of Action(s). Experience with the analytical life cycle management of biopharmaceuticals (particularly antibodies) Preferred Qualifications: If you have the following characteristics, it would be a plus: Experience developing, qualifying and validating GMP cell-based bioassay Experience with Automation particularly Hamilton robotics Experience responding to agency (regulatory) questions Proven record of accomplishments delivering impactful results. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
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