Senior Engineer

Senior Engineer, Vector Core Production

Cambridge, MA USA

Position Summary:

We are seeking a Senior Engineer in Vector Core Production to join our Technical Operations team to lead the production of gene therapy vectors to support Research, Development, and Non-clinical collaborators. The candidate will work closely with a team of scientists to produce, purify, and analyze novel anelloviruses and vectors to enable company-wide research activities. We are searching for driven, enthusiastic, and self-motivated individuals who are comfortable multitasking and working independently on various aspects of vector production and analysis.

Key Responsibilities:

• Manage routine upstream cell culture and virus/vector production and downstream purification operations to produce viruses and viral vectors
• Support the design, implementation, execution, and troubleshooting of experiments in collaboration with Technical Operations, Research, and Translational teams
• Manage and mentor junior staff by planning and assigning duties to meet departmental and organizational objectives. Provide guidance and direction to staff and collaborators.
• Perform basic vector characterization assays such as qPCR, ELISA, SDS-PAGE, and endotoxin as necessary
• Maintain meticulous records of batch productions, process parameters, and process data; manage samples generated throughout batch productions and ensure on-time testing and data generation
• Manage vector lab organization, inventory, and equipment maintenance, and perform other duties as assigned
• Maintain scientific and technical expertise through familiarity with scientific literature and developing relationships with thought leaders

Qualifications:

• Ph.D. (+3 years relevant experience), MS (+5 years), or BS (+7 years) in biochemistry, bioengineering, chemical engineering, virology, or related field
• Hands-on experience of adherent and/or suspension mammalian cell culture, transfection, chromatography, and UF/DF unit operations for the production of biologics or viral vectors
• Working knowledge of various analytical assays such as PCR, ELISA, SDS-PAGE, and cell-based potency assays
• Excellent communication skills and ability to work effectively as a member of a multidisciplinary team
• Demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial, and technical environment
• Strong organizational, time management, and lab notebook upkeep skills, and careful attention to detail

Benefits:

Vacation & sick time

Health & Dental

401k