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Senior Engineer

Boston Lab Services
Boston, MA
Closing date
Sep 17, 2021

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Science, Physical Sciences and Engineering
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Senior Engineer, Vector Core Production

Cambridge, MA USA

Position Summary:

We are seeking a Senior Engineer in Vector Core Production to join our Technical Operations team to lead the production of gene therapy vectors to support Research, Development, and Non-clinical collaborators. The candidate will work closely with a team of scientists to produce, purify, and analyze novel anelloviruses and vectors to enable company-wide research activities. We are searching for driven, enthusiastic, and self-motivated individuals who are comfortable multitasking and working independently on various aspects of vector production and analysis.

Key Responsibilities:
  • Manage routine upstream cell culture and virus/vector production and downstream purification operations to produce viruses and viral vectors
  • Support the design, implementation, execution, and troubleshooting of experiments in collaboration with Technical Operations, Research, and Translational teams
  • Manage and mentor junior staff by planning and assigning duties to meet departmental and organizational objectives. Provide guidance and direction to staff and collaborators.
  • Perform basic vector characterization assays such as qPCR, ELISA, SDS-PAGE, and endotoxin as necessary
  • Maintain meticulous records of batch productions, process parameters, and process data; manage samples generated throughout batch productions and ensure on-time testing and data generation
  • Manage vector lab organization, inventory, and equipment maintenance, and perform other duties as assigned
  • Maintain scientific and technical expertise through familiarity with scientific literature and developing relationships with thought leaders

  • Ph.D. (+3 years relevant experience), MS (+5 years), or BS (+7 years) in biochemistry, bioengineering, chemical engineering, virology, or related field
  • Hands-on experience of adherent and/or suspension mammalian cell culture, transfection, chromatography, and UF/DF unit operations for the production of biologics or viral vectors
  • Working knowledge of various analytical assays such as PCR, ELISA, SDS-PAGE, and cell-based potency assays
  • Excellent communication skills and ability to work effectively as a member of a multidisciplinary team
  • Demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial, and technical environment
  • Strong organizational, time management, and lab notebook upkeep skills, and careful attention to detail


Vacation & sick time

Health & Dental

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